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    Zfp626 zinc finger protein 626 [ Mus musculus (house mouse) ]

    Gene ID: 71163, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp626provided by MGI
    Official Full Name
    zinc finger protein 626provided by MGI
    Primary source
    MGI:MGI:1918413
    See related
    Ensembl:ENSMUSG00000030604 AllianceGenome:MGI:1918413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4833408D11Rik; 4933426I21Rik; 7630402I04Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF780A (zinc finger protein 780A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.5), CNS E11.5 (RPKM 1.5) and 24 other tissues See more
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    Genomic context

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    See Zfp626 in Genome Data Viewer
    Location:
    7 A3; 7 15.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27504165..27522348)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27804731..27822923)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10046 Neighboring gene predicted gene, 29810 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28589770-28589879 Neighboring gene STARR-seq mESC enhancer starr_18392 Neighboring gene zinc finger protein 59 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28645358-28645700 Neighboring gene zinc finger protein 607A Neighboring gene protein kinase C, zeta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 626

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403469.1 → NP_001390398.1  zinc finger protein 626

      Status: VALIDATED

      Source sequence(s)
      AC164532
      UniProtKB/TrEMBL
      A0A0U1RQ84

    2. NM_027703.2 → NP_081979.1  zinc finger protein 626

      Status: VALIDATED

      Source sequence(s)
      AC164532
      Consensus CDS
      CCDS85250.1
      UniProtKB/TrEMBL
      A0A0U1RQ84
      Related
      ENSMUSP00000146286.2, ENSMUST00000205671.2
      Conserved Domains (4) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:170 → 572
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:427 → 447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:607 → 631
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27504165..27522348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312305.1 → XP_017167794.1  zinc finger protein 626 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:129 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:386 → 406
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:2 → 34
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    Nucleotide Protein Strain
    Heading Accession and Version

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