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    Pebp1 phosphatidylethanolamine binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 23980, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pebp1provided by MGI
    Official Full Name
    phosphatidylethanolamine binding protein 1provided by MGI
    Primary source
    MGI:MGI:1344408
    See related
    Ensembl:ENSMUSG00000032959 AllianceGenome:MGI:1344408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pbp; HCNP; Pbp1; Pbpr; Rkip
    Summary
    Predicted to enable ATP binding activity; mitogen-activated protein kinase binding activity; and receptor serine/threonine kinase binding activity. Acts upstream of or within sperm capacitation. Located in cell surface. Is expressed in cerebral cortex ventricular layer; cortical plate; embryo; ovary; and primary sex cord. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 1168.4), adrenal adult (RPKM 808.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pebp1 in Genome Data Viewer
    Location:
    5 F; 5 56.88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117420716..117425629, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117282651..117287564, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene suppressor of defective silencing 3 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E3606 Neighboring gene STARR-positive B cell enhancer ABC_E2172 Neighboring gene STARR-seq mESC enhancer starr_14168 Neighboring gene STARR-positive B cell enhancer ABC_E6369 Neighboring gene TAO kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3607 Neighboring gene STARR-positive B cell enhancer ABC_E3608 Neighboring gene STARR-positive B cell enhancer ABC_E3609 Neighboring gene STARR-seq mESC enhancer starr_14169 Neighboring gene STARR-positive B cell enhancer ABC_E8074 Neighboring gene predicted gene 3786 Neighboring gene cDNA sequence BC051077 Neighboring gene predicted gene, 52828

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein. Chen Y, et al. J Proteome Res, 2011 Jan 7. PMID 21155602
    2. Raf-kinase inhibitor protein attenuates microglia inflammation in an in vitro model of intracerebral hemorrhage. Wang J, et al. Cell Mol Biol (Noisy-le-grand), 2016 May 30. PMID 27262809
    3. Raf-1 Kinase Inhibitory Protein (RKIP) Promotes Retinal Ganglion Cell Survival and Axonal Regeneration Following Optic Nerve Crush. Wei J, et al. J Mol Neurosci, 2015 Oct. PMID 26160696
    4. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression. Huang Q, et al. Int Immunopharmacol, 2017 Jan. PMID 27912149
    5. Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer. Escara-Wilke J, et al. Prostate, 2015 Feb 15. PMID 25327941

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway.
      Title: AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway.
    2. RKIP suppresses the influenza A virusinduced airway inflammatory response via the ERK/MAPK pathway.
      Title: RKIP suppresses the influenza A virus‑induced airway inflammatory response via the ERK/MAPK pathway.
    3. Phosphatidylethanolamine-binding protein 1 (PEBP1) mediates the regulatory role of microRNAs (miRNAs)-205-5p in degranulation and histamine release.
      Title: Phosphatidylethanolamine-binding protein 1 (PEBP1) mediates the regulatory role of microRNAs (miRNAs)-205-5p in degranulation and histamine release.
    4. RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions.
      Title: RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions.
    5. Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage.
      Title: Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage.
    6. Transcriptional regulation of PEBP1 expression by androgen receptor in mouse testes.
      Title: Transcriptional regulation of PEBP1 expression by androgen receptor in mouse testes.
    7. Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
      Title: Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
    8. Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.
      Title: Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.
    9. Axonal Odorant Receptors Mediate Axon Targeting.
      Title: Axonal Odorant Receptors Mediate Axon Targeting.
    10. Theta power in the CA1 of HCNP-pp knockout mice was significantly reduced because of fewer cholineacetyltransferase-positive axons in the CA1 stratum oriens.
      Title: Reduced Cholinergic Activity in the Hippocampus of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein Knockout Mice.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102065, MGC103131

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of acetylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of acetylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm capacitation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylethanolamine-binding protein 1
    Names
    HCNPpp
    PEBP-1
    Raf-1 inhibitor protein
    Raf-1 kinase inhibitor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018858.2 → NP_061346.2  phosphatidylethanolamine-binding protein 1

      See identical proteins and their annotated locations for NP_061346.2

      Status: PROVISIONAL

      Source sequence(s)
      BC083063
      Consensus CDS
      CCDS39234.1
      UniProtKB/Swiss-Prot
      P70296, Q9D8G9, Q9JJ58
      UniProtKB/TrEMBL
      Q3TGC5, Q5EBQ2
      Related
      ENSMUSP00000048425.7, ENSMUST00000036951.13
      Conserved Domains (1) summary
      cd00866
      Location:25 → 171
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      117420716..117425629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70296.3 GenPept UniProtKB/Swiss-Prot:P70296

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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