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    ADGRL3 adhesion G protein-coupled receptor L3 [ Homo sapiens (human) ]

    Gene ID: 23284, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ADGRL3provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor L3provided by HGNC
    Primary source
    HGNC:HGNC:20974
    See related
    Ensembl:ENSG00000150471 MIM:616417; AllianceGenome:HGNC:20974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CL3; LEC3; CIRL3; LPHN3
    Summary
    This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 7.2), adrenal (RPKM 1.9) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRL3 in Genome Data Viewer
    Location:
    4q13.1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (61200326..62078335)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (64638264..65515643)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (62066044..62944053)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:61799272-61800471 Neighboring gene microRNA 548ag-1 Neighboring gene Sharpr-MPRA regulatory region 1933 Neighboring gene long intergenic non-protein coding RNA 2271 Neighboring gene uncharacterized LOC124900173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:62068190-62068762 Neighboring gene ribosomal protein L17 pseudogene 19 Neighboring gene Sharpr-MPRA regulatory region 909 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:62252700-62253638 Neighboring gene Sharpr-MPRA regulatory region 11493 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:62459979-62460480 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62512707-62513321 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62512092-62512706 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:62629970-62630560 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:62630561-62631150 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62633919-62634780 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62634781-62635644 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:62635645-62636506 Neighboring gene ribosomal protein S12 pseudogene 9 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:62776506-62777086 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:62777087-62777665 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:62857945-62858479 Neighboring gene ADGRL3 antisense RNA 1 Neighboring gene uncharacterized LOC101927145 Neighboring gene ribosomal protein S15a pseudogene 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:63071027-63071527

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder. Moreno-Alcázar A, et al. Sci Rep, 2021 Jan 27. PMID 33504901, Free PMC Article
    2. Screening of human LPHN3 for variants with a potential impact on ADHD susceptibility. Domené S, et al. Am J Med Genet B Neuropsychiatr Genet, 2011 Jan. PMID 21184580
    3. Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD. Arcos-Burgos M, et al. Atten Defic Hyperact Disord, 2010 Nov. PMID 21432600, Free PMC Article
    4. Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study. Ribasés M, et al. Genes Brain Behav, 2011 Mar. PMID 21040458
    5. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Arcos-Burgos M, et al. Mol Psychiatry, 2010 Nov. PMID 20157310

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.
      Title: The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.
    2. ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP.
      Title: ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP.
    3. Driver mutations in ADGRL3 are involved in the evolution of ependymoma.
      Title: Driver mutations in ADGRL3 are involved in the evolution of ependymoma.
    4. Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations.
      Title: Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations.
    5. Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.
      Title: Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.
    6. Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25.
      Title: Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25.
    7. Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands.
      Title: Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands.
    8. CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics.
      Title: CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics.
    9. Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder.
      Title: Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder.
    10. Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.
      Title: Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
    EBI GWAS Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L3
    Names
    calcium-independent alpha-latrotoxin receptor 3
    latrophilin homolog 3 (cow)
    latrophilin-3
    lectomedin 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033950.2 RefSeqGene

      Range
      4071..882080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322246.3 → NP_001309175.1  adhesion G protein-coupled receptor L3 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      Consensus CDS
      CCDS82926.1
      UniProtKB/TrEMBL
      E7EMR3
      Related
      ENSP00000423388.1, ENST00000512091.6
      Conserved Domains (8) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1203
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:876 → 901
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:874 → 1140
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001322402.3 → NP_001309331.1  adhesion G protein-coupled receptor L3 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7ETE3
      Conserved Domains (8) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      COG0531
      Location:952 → 1179
      PotE; Amino acid transporter [Amino acid transport and metabolism]
      pfam00002
      Location:942 → 1187
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1537
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 854
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    3. NM_001371342.1 → NP_001358271.1  adhesion G protein-coupled receptor L3 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:796 → 848
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:856 → 1113
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1113 → 1442
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:563 → 770
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    4. NM_001371343.2 → NP_001358272.1  adhesion G protein-coupled receptor L3 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7ETE3
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:864 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:924 → 1181
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1181 → 1510
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 838
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    5. NM_001371344.2 → NP_001358273.1  adhesion G protein-coupled receptor L3 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      Consensus CDS
      CCDS93541.1
      UniProtKB/TrEMBL
      E7ETE3, E7EVD6
      Related
      ENSP00000421372.1, ENST00000507625.5
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1199
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1199 → 1528
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    6. NM_001371345.2 → NP_001358274.1  adhesion G protein-coupled receptor L3 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7ETE3
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:929 → 1186
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1186 → 1515
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 843
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    7. NM_001371346.2 → NP_001358275.1  adhesion G protein-coupled receptor L3 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1126
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1126 → 1455
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:563 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd22846
      Location:29 → 126
      Gal_Rha_Lectin_LPHN3; galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins

    8. NM_001387522.1 → NP_001374451.1  adhesion G protein-coupled receptor L3 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      Consensus CDS
      CCDS93541.1
      UniProtKB/TrEMBL
      E7ETE3, E7EVD6
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1199
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1199 → 1528
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    9. NM_001387523.1 → NP_001374452.1  adhesion G protein-coupled receptor L3 isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7ETE3
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:864 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:924 → 1190
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1190 → 1519
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 838
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    10. NM_001387524.1 → NP_001374453.1  adhesion G protein-coupled receptor L3 isoform 25 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7ETE3
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:864 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:924 → 1181
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1181 → 1510
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 838
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    11. NM_001387525.1 → NP_001374454.1  adhesion G protein-coupled receptor L3 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7ETE3
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:864 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:924 → 1181
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1181 → 1510
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 838
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    12. NM_001387526.1 → NP_001374455.1  adhesion G protein-coupled receptor L3 isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7EW95
      Related
      ENSP00000421627.1, ENST00000508946.5
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1135
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1507
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    13. NM_001387527.1 → NP_001374456.1  adhesion G protein-coupled receptor L3 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1126
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1504
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    14. NM_001387528.1 → NP_001374457.1  adhesion G protein-coupled receptor L3 isoform 26 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7EW95
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:874 → 1140
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1475
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    15. NM_001387529.1 → NP_001374458.1  adhesion G protein-coupled receptor L3 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      Consensus CDS
      CCDS54768.1
      UniProtKB/TrEMBL
      E7EW95
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:874 → 1140
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1469
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    16. NM_001387530.1 → NP_001374459.1  adhesion G protein-coupled receptor L3 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7EW95
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1135
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1464
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    17. NM_001387531.1 → NP_001374460.1  adhesion G protein-coupled receptor L3 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7EW95
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1135
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1464
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    18. NM_001387532.1 → NP_001374461.1  adhesion G protein-coupled receptor L3 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7EW95
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1135
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1464
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    19. NM_001387533.1 → NP_001374462.1  adhesion G protein-coupled receptor L3 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Related
      ENSP00000424258.1, ENST00000514996.5
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:874 → 1131
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1131 → 1460
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    20. NM_001387534.1 → NP_001374463.1  adhesion G protein-coupled receptor L3 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:874 → 1131
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1131 → 1460
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    21. NM_001387535.1 → NP_001374464.1  adhesion G protein-coupled receptor L3 isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1126
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1455
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    22. NM_001387536.1 → NP_001374465.1  adhesion G protein-coupled receptor L3 isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1126
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1455
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    23. NM_001387537.1 → NP_001374466.1  adhesion G protein-coupled receptor L3 isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/Swiss-Prot
      E9PE04, O94867, Q9HAR2, Q9NWK5
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:801 → 853
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:861 → 1118
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1118 → 1447
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 775
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    24. NM_001387538.1 → NP_001374467.1  adhesion G protein-coupled receptor L3 isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/Swiss-Prot
      E9PE04, O94867, Q9HAR2, Q9NWK5
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:801 → 853
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:861 → 1118
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1118 → 1447
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 775
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    25. NM_001387539.1 → NP_001374468.1  adhesion G protein-coupled receptor L3 isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/Swiss-Prot
      E9PE04, O94867, Q9HAR2, Q9NWK5
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:801 → 853
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:861 → 1118
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1118 → 1447
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 775
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    26. NM_001387540.1 → NP_001374469.1  adhesion G protein-coupled receptor L3 isoform 24 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:796 → 848
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:856 → 1113
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1113 → 1442
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 770
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    27. NM_001387541.1 → NP_001374470.1  adhesion G protein-coupled receptor L3 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (7) summary
      smart00284
      Location:111 → 367
      OLF; Olfactomedin-like domains
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      cd16005
      Location:848 → 1105
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:17 → 97
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1105 → 1434
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:541 → 762
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    28. NM_001387542.1 → NP_001374471.1  adhesion G protein-coupled receptor L3 isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1416
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:866 → 888
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:861 → 1087
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    29. NM_001387543.1 → NP_001374472.1  adhesion G protein-coupled receptor L3 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (6) summary
      smart00284
      Location:43 → 299
      OLF; Olfactomedin-like domains
      smart00303
      Location:715 → 767
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:396 → 460
      HormR; Domain present in hormone receptors
      cd16005
      Location:775 → 1032
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1032 → 1361
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:468 → 689
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    30. NM_001387544.1 → NP_001374473.1  adhesion G protein-coupled receptor L3 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E9PBG4
      Conserved Domains (6) summary
      smart00284
      Location:43 → 299
      OLF; Olfactomedin-like domains
      smart00303
      Location:715 → 767
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:396 → 460
      HormR; Domain present in hormone receptors
      cd16005
      Location:775 → 1032
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1032 → 1361
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:468 → 689
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    31. NM_001387545.1 → NP_001374474.1  adhesion G protein-coupled receptor L3 isoform 19 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      Consensus CDS
      CCDS93539.1
      UniProtKB/TrEMBL
      E7EN28, E7EUP0
      Conserved Domains (8) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1271
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:944 → 969
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:942 → 1208
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    32. NM_001387546.1 → NP_001374475.1  adhesion G protein-coupled receptor L3 isoform 20 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7ENK1
      Related
      ENSP00000423434.1, ENST00000504896.5
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1242
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1135
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    33. NM_001387547.1 → NP_001374476.1  adhesion G protein-coupled receptor L3 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      Consensus CDS
      CCDS82926.1
      UniProtKB/TrEMBL
      E7EMR3
      Conserved Domains (8) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1203
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:876 → 901
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:874 → 1140
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    34. NM_001387548.1 → NP_001374477.1  adhesion G protein-coupled receptor L3 isoform 21 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7EMR3
      Conserved Domains (8) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1198
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1135
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    35. NM_001387549.1 → NP_001374478.1  adhesion G protein-coupled receptor L3 isoform 22 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      UniProtKB/TrEMBL
      E7EMR3
      Related
      ENSP00000424120.1, ENST00000506700.5
      Conserved Domains (8) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1189
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1126
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    36. NM_001387552.1 → NP_001374481.1  adhesion G protein-coupled receptor L3 isoform 23 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      Consensus CDS
      CCDS93538.1
      UniProtKB/TrEMBL
      A0A804HKL8, E7ETE3
      Related
      ENSP00000507980.1, ENST00000683033.1
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1208
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1543
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    37. NM_015236.7 → NP_056051.2  adhesion G protein-coupled receptor L3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_056051.2

      Status: REVIEWED

      Source sequence(s)
      AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
      Consensus CDS
      CCDS54768.1
      UniProtKB/TrEMBL
      E7EW95
      Related
      ENSP00000422533.1, ENST00000514591.5
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:874 → 1140
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1469
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      61200326..62078335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449940.1 → XP_047305896.1  adhesion G protein-coupled receptor L3 isoform X14

      Conserved Domains (7) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1126
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1126 → 1455
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:563 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd22846
      Location:29 → 126
      Gal_Rha_Lectin_LPHN3; galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins

    2. XM_047449941.1 → XP_047305897.1  adhesion G protein-coupled receptor L3 isoform X15

    3. XM_017007929.2 → XP_016863418.1  adhesion G protein-coupled receptor L3 isoform X1

      UniProtKB/TrEMBL
      E7ETE3

    4. XM_017007931.1 → XP_016863420.1  adhesion G protein-coupled receptor L3 isoform X2

      UniProtKB/TrEMBL
      E7ETE3, E7EUW2
      Related
      ENSP00000420931.1, ENST00000506720.5

    5. XM_017007940.1 → XP_016863429.1  adhesion G protein-coupled receptor L3 isoform X16

      UniProtKB/TrEMBL
      E7EN28, E7EUP0
      Related
      ENSP00000423787.1, ENST00000509896.5
      Conserved Domains (8) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1271
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:944 → 969
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:942 → 1208
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_017007941.1 → XP_016863430.1  adhesion G protein-coupled receptor L3 isoform X18

      UniProtKB/TrEMBL
      E7ESV6, E7EX52
      Related
      ENSP00000425033.1, ENST00000511324.5

    7. XM_017007933.1 → XP_016863422.1  adhesion G protein-coupled receptor L3 isoform X6

      UniProtKB/TrEMBL
      E7ETE3

    8. XM_017007936.1 → XP_016863425.1  adhesion G protein-coupled receptor L3 isoform X8

      UniProtKB/TrEMBL
      E7ETE3

    9. XM_047449935.1 → XP_047305891.1  adhesion G protein-coupled receptor L3 isoform X4

    10. XM_011531791.2 → XP_011530093.1  adhesion G protein-coupled receptor L3 isoform X12

      UniProtKB/TrEMBL
      E7ETE3
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:929 → 1186
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1186 → 1515
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 843
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    11. XM_047449934.1 → XP_047305890.1  adhesion G protein-coupled receptor L3 isoform X3

    12. XM_047449942.1 → XP_047305898.1  adhesion G protein-coupled receptor L3 isoform X17

    13. XM_017007934.1 → XP_016863423.1  adhesion G protein-coupled receptor L3 isoform X7

      UniProtKB/TrEMBL
      E7ETE3

    14. XM_047449943.1 → XP_047305899.1  adhesion G protein-coupled receptor L3 isoform X19

    15. XM_047449937.1 → XP_047305893.1  adhesion G protein-coupled receptor L3 isoform X9

    16. XM_047449936.1 → XP_047305892.1  adhesion G protein-coupled receptor L3 isoform X5

    17. XM_047449938.1 → XP_047305894.1  adhesion G protein-coupled receptor L3 isoform X10

    18. XM_047449939.1 → XP_047305895.1  adhesion G protein-coupled receptor L3 isoform X13

    19. XM_047449944.1 → XP_047305900.1  adhesion G protein-coupled receptor L3 isoform X20

      Related
      ENSP00000421476.1, ENST00000507164.5

    20. XM_047449945.1 → XP_047305901.1  adhesion G protein-coupled receptor L3 isoform X21

    21. XM_017007930.1 → XP_016863419.1  adhesion G protein-coupled receptor L3 isoform X1

      UniProtKB/TrEMBL
      E7ETE3

    22. XM_017007937.1 → XP_016863426.1  adhesion G protein-coupled receptor L3 isoform X11

      UniProtKB/TrEMBL
      E7EW95

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      64638264..65515643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349474.1 → XP_054205449.1  adhesion G protein-coupled receptor L3 isoform X14

    2. XM_054349475.1 → XP_054205450.1  adhesion G protein-coupled receptor L3 isoform X15

    3. XM_054349460.1 → XP_054205435.1  adhesion G protein-coupled receptor L3 isoform X1

    4. XM_054349461.1 → XP_054205436.1  adhesion G protein-coupled receptor L3 isoform X2

      UniProtKB/TrEMBL
      E7EUW2

    5. XM_054349477.1 → XP_054205452.1  adhesion G protein-coupled receptor L3 isoform X16

      UniProtKB/TrEMBL
      E7EUP0

    6. XM_054349479.1 → XP_054205454.1  adhesion G protein-coupled receptor L3 isoform X18

      UniProtKB/TrEMBL
      E7ESV6

    7. XM_054349465.1 → XP_054205440.1  adhesion G protein-coupled receptor L3 isoform X6

    8. XM_054349467.1 → XP_054205442.1  adhesion G protein-coupled receptor L3 isoform X8

    9. XM_054349463.1 → XP_054205438.1  adhesion G protein-coupled receptor L3 isoform X4

    10. XM_054349471.1 → XP_054205446.1  adhesion G protein-coupled receptor L3 isoform X12

    11. XM_054349462.1 → XP_054205437.1  adhesion G protein-coupled receptor L3 isoform X3

    12. XM_054349478.1 → XP_054205453.1  adhesion G protein-coupled receptor L3 isoform X17

    13. XM_054349466.1 → XP_054205441.1  adhesion G protein-coupled receptor L3 isoform X7

    14. XM_054349480.1 → XP_054205455.1  adhesion G protein-coupled receptor L3 isoform X19

    15. XM_054349468.1 → XP_054205443.1  adhesion G protein-coupled receptor L3 isoform X9

    16. XM_054349464.1 → XP_054205439.1  adhesion G protein-coupled receptor L3 isoform X5

    17. XM_054349469.1 → XP_054205444.1  adhesion G protein-coupled receptor L3 isoform X10

    18. XM_054349472.1 → XP_054205447.1  adhesion G protein-coupled receptor L3 isoform X22

    19. XM_054349473.1 → XP_054205448.1  adhesion G protein-coupled receptor L3 isoform X13

    20. XM_054349481.1 → XP_054205456.1  adhesion G protein-coupled receptor L3 isoform X20

    21. XM_054349482.1 → XP_054205457.1  adhesion G protein-coupled receptor L3 isoform X21

    22. XM_054349476.1 → XP_054205451.1  adhesion G protein-coupled receptor L3 isoform X23

    23. XM_054349459.1 → XP_054205434.1  adhesion G protein-coupled receptor L3 isoform X1

    24. XM_054349470.1 → XP_054205445.1  adhesion G protein-coupled receptor L3 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HAR2.2 GenPept UniProtKB/Swiss-Prot:Q9HAR2

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