spsb1 splA/ryanodine receptor domain and SOCS box containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spsb1provided by ZNC
Official Full Name: splA/ryanodine receptor domain and SOCS box containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6122
See related: Ensembl:ENSDARG00000056515 AllianceGenome:ZFIN:ZDB-GENE-030131-6122
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi35c01; wu:fi35c01; zgc:114115
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; gonad; muscle; and otic vesicle. Orthologous to human SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (22496423..22523303, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (22569872..22596752, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SSB-1 transcripts were present in all blastomeres during the early embryonic stages. SSB-4 mRNA was located in the region of the primordial germ cells in 24 and 72 hpf embryos, but SSB-1 mRNA was not detected at these stages.
Title: Cloning and characterization of the SSB-1 and SSB-4 genes expressed in zebrafish gonads.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SPRY domain-containing SOCS box protein 1

Names: ssb-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025460.1 → NP_001020631.1 SPRY domain-containing SOCS box protein 1

See identical proteins and their annotated locations for NP_001020631.1

Status: PROVISIONAL

Source sequence(s)

BC097174

UniProtKB/TrEMBL

A0A8M1N6V2, Q4V8W1

Related

ENSDARP00000073475.3, ENSDART00000079019.4

Conserved Domains (2) summary

cd03718
Location:232 → 273

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:54 → 227

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)