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    skp2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 563708, updated on 18-Sep-2024

    Summary

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    Official Symbol
    skp2provided by ZNC
    Official Full Name
    S-phase kinase-associated protein 2, E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-158
    See related
    Ensembl:ENSDARG00000004937 AllianceGenome:ZFIN:ZDB-GENE-030219-158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb933; id:ibd5121; wu:fa10b08; wu:fj97b11; zgc:162950
    Summary
    Predicted to be involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and regulation of cell cycle. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; intermediate cell mass of mesoderm; nervous system; and ventral mesoderm. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See skp2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22347120..22357987, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22310484..22321351, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4b Neighboring gene NAD kinase 2, mitochondrial Neighboring gene uncharacterized LOC137488808 Neighboring gene uncharacterized LOC137488809 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential response of multiple zebrafish hepatic F-box protein genes to 17alpha-ethinylestradiol treatment. Zheng H, et al. J Environ Sci (China), 2011. PMID 21793410
    2. Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis. Uribe RA, et al. Dev Biol, 2012 Nov 15. PMID 22981606, Free PMC Article
    3. MYCN transgenic zebrafish model with the characterization of acute myeloid leukemia and altered hematopoiesis. Shen LJ, et al. PLoS One, 2013. PMID 23554972, Free PMC Article
    4. RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. Shen L, et al. BMC Cancer, 2015 Dec 16. PMID 26674644, Free PMC Article
    5. Genome-wide analysis of facial skeletal regionalization in zebrafish. Askary A, et al. Development, 2017 Aug 15. PMID 28705894, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-phase kinase-associated protein 2
    Names
    S-phase kinase-associated protein 2 (p45)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082837.2 → NP_001076306.1  S-phase kinase-associated protein 2

      See identical proteins and their annotated locations for NP_001076306.1

      Status: VALIDATED

      Source sequence(s)
      BC134165, BX470072, CT679586
      UniProtKB/TrEMBL
      A0A8M1NBV0, A3KP53
      Related
      ENSDARP00000092527.3, ENSDART00000101751.5
      Conserved Domains (3) summary
      cd09293
      Location:173 → 324
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:151 → 173
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:88 → 133
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      22347120..22357987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161189.5 → XP_005161246.1  S-phase kinase-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B860
      Conserved Domains (3) summary
      cd09293
      Location:190 → 341
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:168 → 190
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:105 → 150
      F-box-like; F-box-like

    2. XM_068215914.1 → XP_068072015.1  S-phase kinase-associated protein 2 isoform X2

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395349.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      487041..497908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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