eno1a enolase 1a, (alpha) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eno1aprovided by ZNC
Official Full Name: enolase 1a, (alpha)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6048
See related: Ensembl:ENSDARG00000022456 AllianceGenome:ZFIN:ZDB-GENE-030131-6048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eno1; zgc:73152; wu:fi32b03; wu:fk58e02
Summary: Predicted to enable phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. Predicted to be part of phosphopyruvate hydratase complex. Is expressed in several structures, including axis; margin; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (22656545..22677845)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (22729939..22751294)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphopyruvate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphopyruvate hydratase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of phosphopyruvate hydratase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphopyruvate hydratase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: enolase 1a, (alpha)

Names: enolase 1, (alpha)

NP_997887.1

EC 4.2.1.11

XP_005162209.1

EC 4.2.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212722.1 → NP_997887.1 enolase 1a, (alpha)

See identical proteins and their annotated locations for NP_997887.1

Status: PROVISIONAL

Source sequence(s)

BC071359

UniProtKB/TrEMBL

Q6IQP5

Related

ENSDARP00000003738.5, ENSDART00000009337.7

Conserved Domains (2) summary

PLN00191
Location:2 → 431

PLN00191; enolase

cd03313
Location:5 → 416

enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

22656545..22677845

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162152.5 → XP_005162209.1 enolase 1a, (alpha) isoform X1

UniProtKB/TrEMBL

A0A2R8Q1X2, A0A8M2B8Z4

Related

ENSDARP00000144676.1, ENSDART00000192248.1

Conserved Domains (2) summary

PLN00191
Location:2 → 431

PLN00191; enolase

cd03313
Location:5 → 416

enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.