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    dip2ba disco-interacting protein 2 homolog Ba [ Danio rerio (zebrafish) ]

    Gene ID: 405899, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dip2baprovided by ZNC
    Official Full Name
    disco-interacting protein 2 homolog Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2305
    See related
    Ensembl:ENSDARG00000005350 AllianceGenome:ZFIN:ZDB-GENE-040426-2305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dip2b; zgc:77348
    Summary
    Predicted to be involved in negative regulation of axon extension and positive regulation of peptidyl-lysine acetylation. Predicted to act upstream of or within nervous system development. Predicted to be located in axon; dendrite; and perikaryon. Is expressed in axial mesoderm and notochord. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2B (disco interacting protein 2 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dip2ba in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (27358722..27442546, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (27432181..27516027, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene acrosin Neighboring gene si:dkey-9p24.5 Neighboring gene activating transcription factor 7a Neighboring gene ankyrin repeat and SOCS box containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Bouwmeester MC, et al. Toxicol Appl Pharmacol, 2016 Jan 15. PMID 26712470
    2. A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Dong Z, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Jan. PMID 33069857
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC77348

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of peptidyl-lysine acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    disco-interacting protein 2 homolog B-A
    Names
    DIP2 disco-interacting protein 2 homolog B
    DIP2 disco-interacting protein 2 homolog Ba
    DIP2 homolog B
    DIP2 homolog B-A
    disco-interacting protein 2 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212963.1 → NP_998128.1  disco-interacting protein 2 homolog B-A

      See identical proteins and their annotated locations for NP_998128.1

      Status: PROVISIONAL

      Source sequence(s)
      BC068015
      UniProtKB/Swiss-Prot
      Q6NVJ5
      Related
      ENSDARP00000019936.9, ENSDART00000019521.11
      Conserved Domains (4) summary
      cd05905
      Location:361 → 925
      Dip2; Disco-interacting protein 2 (Dip2)
      COG0318
      Location:337 → 913
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      pfam00501
      Location:997 → 1471
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:8 → 124
      DMAP_binding; DMAP1-binding Domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      27358722..27442546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296841.4 → XP_009295116.1  disco-interacting protein 2 homolog B-A isoform X1

      UniProtKB/TrEMBL
      A0A8M3AYD4
      Conserved Domains (4) summary
      cd05905
      Location:361 → 925
      Dip2; Disco-interacting protein 2 (Dip2)
      COG0318
      Location:337 → 913
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      pfam00501
      Location:1005 → 1479
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:8 → 124
      DMAP_binding; DMAP1-binding Domain

    2. XM_068216719.1 → XP_068072820.1  disco-interacting protein 2 homolog B-A isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NVJ5.1 GenPept UniProtKB/Swiss-Prot:Q6NVJ5

    Gene LinkOut

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