mtx2 metaxin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtx2provided by ZNC
Official Full Name: metaxin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-021210-2
See related: Ensembl:ENSDARG00000029415 AllianceGenome:ZFIN:ZDB-GENE-021210-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc02d09; wu:fc02d09
Summary: Predicted to be involved in mitochondrion organization. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Is expressed in blastoderm and female organism. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (10871731..10879963)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (10636304..10644536)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mtx2 acts within the YSL to regulate morphogenetic movements of both embryonic and extra-embryonic tissues, independently of cell fate specification.
Title: Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation.
knockdown leads to an inhibition of epiboly in gastrulation
Title: T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SAM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAM complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: metaxin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212575.2 → NP_997740.1 metaxin-2

See identical proteins and their annotated locations for NP_997740.1

Status: PROVISIONAL

Source sequence(s)

AY289938

UniProtKB/TrEMBL

B2GQ68, Q6WFZ4

Related

ENSDARP00000041857.6, ENSDART00000041858.7

Conserved Domains (3) summary

cd03211
Location:125 → 250

GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2

COG0625
Location:33 → 260

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03079
Location:22 → 95

GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...