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    sik3 SIK family kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 393513, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sik3provided by ZNC
    Official Full Name
    SIK family kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-140106-203
    See related
    AllianceGenome:ZFIN:ZDB-GENE-140106-203
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66101; zgc:85904
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in intracellular signal transduction; microtubule cytoskeleton organization; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See sik3 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (47501589..47578930)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (46832243..47025640, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene paired like homeobox 2A Neighboring gene inositol polyphosphate phosphatase-like 1a Neighboring gene uncharacterized LOC101884560 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene uncharacterized LOC101883079 Neighboring gene transmembrane protein 25 Neighboring gene centrosomal protein 164

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA structure replaces the need for U2AF2 in splicing. Lin CL, et al. Genome Res, 2016 Jan. PMID 26566657, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66101

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SIK3 homolog
    Names
    serine/threonine-protein kinase QSK homolog
    zmp:0000001243
    NP_956835.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200541.1 → NP_956835.1  serine/threonine-protein kinase SIK3 homolog

      See identical proteins and their annotated locations for NP_956835.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056316
      UniProtKB/Swiss-Prot
      Q6NSM8, Q6PHV1
      Conserved Domains (3) summary
      smart00220
      Location:61 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14071
      Location:60 → 312
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
      cl21463
      Location:341 → 385
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      47501589..47578930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NSM8.1 GenPept UniProtKB/Swiss-Prot:Q6NSM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials