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    kbtbd2 kelch repeat and BTB (POZ) domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 563254, updated on 28-Oct-2024

    Summary

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    Official Symbol
    kbtbd2provided by ZNC
    Official Full Name
    kelch repeat and BTB (POZ) domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-1262
    See related
    Ensembl:ENSDARG00000087226 AllianceGenome:ZFIN:ZDB-GENE-060929-1262
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7146937; zgc:152954
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KBTBD2 (kelch repeat and BTB domain containing 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kbtbd2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (14150043..14162781)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (14111740..14124478)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:ch211-217a12.1 Neighboring gene bucky ball 2-like Neighboring gene AVL9 homolog (S. cerevisiase) Neighboring gene uncharacterized LOC110440141 Neighboring gene mitochondrial tRNA translation optimization 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Multiplicity of Buc copies in Atlantic salmon contrasts with loss of the germ cell determinant in primates, rodents and axolotl. Škugor A, et al. BMC Evol Biol, 2016 Oct 26. PMID 27784263, Free PMC Article
    2. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC152954

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch repeat and BTB domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077160.2 → NP_001070628.1  kelch repeat and BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_001070628.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124190
      UniProtKB/TrEMBL
      A0A8M1NA21, Q08CL1
      Related
      ENSDARP00000110552.1, ENSDART00000123741.3
      Conserved Domains (5) summary
      PHA03098
      Location:24 → 524
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:317 → 374
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:25 → 126
      BTB; BTB/POZ domain
      pfam01344
      Location:377 → 424
      Kelch_1; Kelch motif
      pfam07707
      Location:134 → 228
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      14150043..14162781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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