nmrk2 nicotinamide riboside kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nmrk2provided by ZNC
Official Full Name: nicotinamide riboside kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-44
See related: Ensembl:ENSDARG00000067848 AllianceGenome:ZFIN:ZDB-GENE-040912-44
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: itgb1bp3; zgc:103408
Summary: Predicted to enable ribosylnicotinamide kinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (55982946..55990661)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (55859101..55866816)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosylnicotinamide kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nicotinamide riboside kinase 2

Names: integrin beta 1 binding protein 3

NP_001004618.2

EC 2.7.1.-

EC 2.7.1.173

EC 2.7.1.22

NP_001314713.1

EC 2.7.1.-

EC 2.7.1.173

EC 2.7.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004618.2 → NP_001004618.2 nicotinamide riboside kinase 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

CU013534

UniProtKB/TrEMBL

A0A8M1N287, F1QSP0

Related

ENSDARP00000088522.4, ENSDART00000097751.5
NM_001327784.1 → NP_001314713.1 nicotinamide riboside kinase 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CU013534, EH432193, EH485974, EH594583

UniProtKB/TrEMBL

A0A8M1P907, F1QSN9

Related

ENSDARP00000088524.4, ENSDART00000097753.6

Conserved Domains (1) summary

cd02024
Location:4 → 167

NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...