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    fam168a family with sequence similarity 168 member A [ Danio rerio (zebrafish) ]

    Gene ID: 751761, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fam168aprovided by ZNC
    Official Full Name
    family with sequence similarity 168 member Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-128
    See related
    Ensembl:ENSDARG00000098832 AllianceGenome:ZFIN:ZDB-GENE-060825-128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153007
    Summary
    Predicted to be involved in positive regulation of base-excision repair. Is expressed in brain. Orthologous to human FAM168A (family with sequence similarity 168 member A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fam168a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (2837563..2935707)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (6551956..6650253)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene RELT TNF receptor Neighboring gene Rho guanine nucleotide exchange factor (GEF) 17 Neighboring gene rho guanine nucleotide exchange factor 17 Neighboring gene pyrimidinergic receptor P2Y6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation. Zhang T, et al. Biochim Biophys Acta Gene Regul Mech, 2020 Oct. PMID 32745624
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153007

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM168A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045470.2 → NP_001038935.2  protein FAM168A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      EH438334, EH582125, EH601884
      UniProtKB/TrEMBL
      A0A0H2UKU6, A0A8M1NAQ8
      Related
      ENSDARP00000139676.1, ENSDART00000160228.2
      Conserved Domains (1) summary
      pfam14944
      Location:32 → 224
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    2. NM_001244879.1 → NP_001231808.1  protein FAM168A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      EH438334, EH582125, EH601884
      UniProtKB/TrEMBL
      A0A0H2UKW4, A0A8M1P263
      Related
      ENSDARP00000140889.1, ENSDART00000171495.2
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 235
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      2837563..2935707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173612.5 → XP_005173669.1  protein FAM168A isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKV9
      Conserved Domains (1) summary
      pfam14944
      Location:32 → 266
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    2. XM_005173614.5 → XP_005173671.1  protein FAM168A isoform X2

      UniProtKB/TrEMBL
      A0A8M2BKV3
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 193
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
    Nucleotide Protein Strain
    Heading Accession and Version

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