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    lman2 lectin, mannose-binding 2 [ Danio rerio (zebrafish) ]

    Gene ID: 557960, updated on 28-Oct-2024

    Summary

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    Official Symbol
    lman2provided by ZNC
    Official Full Name
    lectin, mannose-binding 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070209-149
    See related
    Ensembl:ENSDARG00000061854 AllianceGenome:ZFIN:ZDB-GENE-070209-149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb16f04; zgc:158761
    Summary
    Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human LMAN2 (lectin, mannose binding 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lman2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (26413417..26425387, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (26115312..26127282, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 212 Neighboring gene transmembrane p24 trafficking protein 9 Neighboring gene phospholipase D family, member 7 Neighboring gene G protein-coupled receptor 137

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos. Hickey GJ, et al. Elife, 2022 Jan 4. PMID 34982026, Free PMC Article
    2. Thyroid disrupting effects of halogenated and next generation chemicals on the swim bladder development of zebrafish. Godfrey A, et al. Aquat Toxicol, 2017 Dec. PMID 29101780
    3. Gene expression profiling in the skin of zebrafish infected with Citrobacter freundii. Lü A, et al. Fish Shellfish Immunol, 2012 Feb. PMID 22155693
    4. Insulin-like growth factor (IGF) signalling and genome-wide transcriptional regulation in fast muscle of zebrafish following a single-satiating meal. Amaral IP, et al. J Exp Biol, 2011 Jul 1. PMID 21653807
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158761

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vesicular integral-membrane protein VIP36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081747.2 → NP_001075216.2  vesicular integral-membrane protein VIP36 precursor

      Status: VALIDATED

      Source sequence(s)
      BC133153, BX323077, EH442331
      UniProtKB/TrEMBL
      A0A8M1NBX2, A2RV32, A5PMC4
      Related
      ENSDARP00000083123.5, ENSDART00000088690.6
      Conserved Domains (1) summary
      cd06901
      Location:50 → 299
      lectin_VIP36_VIPL; VIP36 and VIPL type 1 transmembrane proteins, lectin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      26413417..26425387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173172.5 → XP_005173229.1  vesicular integral-membrane protein VIP36 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKH4, A2RV32
      Conserved Domains (1) summary
      cd06901
      Location:50 → 298
      lectin_VIP36_VIPL; VIP36 and VIPL type 1 transmembrane proteins, lectin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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