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    tenm4 teneurin transmembrane protein 4 [ Danio rerio (zebrafish) ]

    Gene ID: 30156, updated on 28-Oct-2024

    Summary

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    Official Symbol
    tenm4provided by ZNC
    Official Full Name
    teneurin transmembrane protein 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990714-20
    See related
    Ensembl:ENSDARG00000105088 AllianceGenome:ZFIN:ZDB-GENE-990714-20
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    odz4; ten-4; ten-m4
    Summary
    Predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Acts upstream of or within axon guidance. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including brain; midbrain hindbrain boundary neural rod; neural tube; optic vesicle; and retina. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tenm4 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (10001466..10455463, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (10079292..10533098, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain-containing protein 3 Neighboring gene proline-rich proteoglycan 2-like Neighboring gene uncharacterized LOC137487718 Neighboring gene uncharacterized LOC110437888 Neighboring gene uncharacterized protein F54H12.2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptional silencing and reactivation in transgenic zebrafish. Goll MG, et al. Genetics, 2009 Jul. PMID 19433629, Free PMC Article
    2. Expression and Roles of Teneurins in Zebrafish. Cheung A, et al. Front Neurosci, 2019. PMID 30914911, Free PMC Article
    3. Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor. Hor H, et al. Hum Mol Genet, 2015 Oct 15. PMID 26188006, Free PMC Article
    4. Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Wang D, et al. J Hazard Mater, 2021 Jul 5. PMID 33621777
    5. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system myelin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gastrulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    teneurin-4
    Names
    protein Odd Oz/ten-m homolog 4
    tenascin-M4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130969.2 → NP_571044.2  teneurin-4

      Status: VALIDATED

      Source sequence(s)
      AL807754, CU856523, CU928223, CU929551
      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A0R4IN22, A0A8N7UZE9
      Related
      ENSDARP00000136839.1, ENSDART00000165668.2
      Conserved Domains (10) summary
      COG3209
      Location:1737 → 2487
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1294 → 1331
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2438 → 2516
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:728 → 900
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1733 → 1768
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 411
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:702 → 728
      EGF_2; EGF-like domain
      pfam15636
      Location:2742 → 2817
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1284 → 1616
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:816 → 857
      DSL; Delta serrate ligand

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      10001466..10455463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213455.1 → XP_068069556.1  teneurin-4 isoform X1

    2. XM_009291510.4 → XP_009289785.1  teneurin-4 isoform X8

      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A8M3B0T4
      Related
      ENSDARP00000146538.1, ENSDART00000192971.1
      Conserved Domains (10) summary
      COG3209
      Location:1680 → 2430
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1230 → 1269
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2381 → 2459
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:625 → 773
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1676 → 1711
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 338
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:629 → 655
      EGF_2; EGF-like domain
      pfam15636
      Location:2685 → 2760
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1220 → 1559
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:743 → 784
      DSL; Delta serrate ligand

    3. XM_068213456.1 → XP_068069557.1  teneurin-4 isoform X5

    4. XM_009291511.4 → XP_009289786.1  teneurin-4 isoform X9

      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A8M3AIB8
      Conserved Domains (10) summary
      COG3209
      Location:1704 → 2454
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1261 → 1298
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2405 → 2483
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:695 → 867
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1700 → 1735
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 378
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:669 → 695
      EGF_2; EGF-like domain
      pfam15636
      Location:2709 → 2784
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1251 → 1583
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:783 → 824
      DSL; Delta serrate ligand

    5. XM_009291509.4 → XP_009289784.1  teneurin-4 isoform X7

      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A2R8RZ80, A0A8M3AH53
      Related
      ENSDARP00000156466.1, ENSDART00000185071.1
      Conserved Domains (10) summary
      COG3209
      Location:1711 → 2461
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1261 → 1300
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2412 → 2490
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:695 → 867
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1707 → 1742
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 378
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:669 → 695
      EGF_2; EGF-like domain
      pfam15636
      Location:2716 → 2791
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1251 → 1590
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:783 → 824
      DSL; Delta serrate ligand

    6. XM_009291508.4 → XP_009289783.1  teneurin-4 isoform X6

      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A8M3APL5
      Conserved Domains (10) summary
      COG3209
      Location:1720 → 2470
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1270 → 1309
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2421 → 2499
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:665 → 813
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1716 → 1751
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 378
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:669 → 695
      EGF_2; EGF-like domain
      pfam15636
      Location:2725 → 2800
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1260 → 1599
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:783 → 824
      DSL; Delta serrate ligand

    7. XM_005157483.5 → XP_005157540.1  teneurin-4 isoform X4

      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A0R4ICV6, A0A8M2B3L7
      Related
      ENSDARP00000132551.1, ENSDART00000162133.2
      Conserved Domains (10) summary
      COG3209
      Location:1744 → 2494
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1294 → 1333
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2445 → 2523
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:728 → 900
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1740 → 1775
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 411
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:702 → 728
      EGF_2; EGF-like domain
      pfam15636
      Location:2749 → 2824
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1284 → 1623
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:816 → 857
      DSL; Delta serrate ligand

    8. XM_009291505.4 → XP_009289780.1  teneurin-4 isoform X2

      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A8M3AIB4
      Conserved Domains (10) summary
      COG3209
      Location:1746 → 2496
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1303 → 1340
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2447 → 2525
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:698 → 846
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1742 → 1777
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 411
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:702 → 728
      EGF_2; EGF-like domain
      pfam15636
      Location:2751 → 2826
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1293 → 1625
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:816 → 857
      DSL; Delta serrate ligand

    9. XM_009291504.4 → XP_009289779.1  teneurin-4 isoform X1

      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A2R8QIZ5, A0A8M3B0S9
      Related
      ENSDARP00000155205.1, ENSDART00000192444.1
      Conserved Domains (10) summary
      COG3209
      Location:1753 → 2503
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1303 → 1342
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2454 → 2532
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:698 → 846
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1749 → 1784
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 411
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:702 → 728
      EGF_2; EGF-like domain
      pfam15636
      Location:2758 → 2833
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1293 → 1632
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:816 → 857
      DSL; Delta serrate ligand

    10. XM_009291506.4 → XP_009289781.1  teneurin-4 isoform X3

      UniProtKB/Swiss-Prot
      Q9W7R3
      UniProtKB/TrEMBL
      A0A8M3ASI0
      Conserved Domains (10) summary
      COG3209
      Location:1745 → 2495
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1295 → 1334
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2446 → 2524
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:690 → 838
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1741 → 1776
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11 → 403
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:694 → 720
      EGF_2; EGF-like domain
      pfam15636
      Location:2750 → 2825
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1285 → 1624
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:808 → 849
      DSL; Delta serrate ligand
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W7R3.1 GenPept UniProtKB/Swiss-Prot:Q9W7R3

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