ppp1r8b protein phosphatase 1, regulatory subunit 8b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppp1r8bprovided by ZNC
Official Full Name: protein phosphatase 1, regulatory subunit 8bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1271
See related: Ensembl:ENSDARG00000022430 AllianceGenome:ZFIN:ZDB-GENE-040426-1271
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PPP1R8; zgc:63827
Summary: Predicted to enable mRNA binding activity and protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in negative regulation of protein dephosphorylation. Predicted to be active in nuclear speck. Orthologous to human PPP1R8 (protein phosphatase 1 regulatory subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (4513597..4531657, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (4685172..4702368, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb68h02 (e-PCR)
- UniSTS:189093

fb68h07 (e-PCR)
- UniSTS:189094

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 1, regulatory subunit 8b

Names: protein phosphatase 1, regulatory (inhibitor) subunit 8b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201200.1 → NP_957494.1 protein phosphatase 1, regulatory subunit 8b

See identical proteins and their annotated locations for NP_957494.1

Status: PROVISIONAL

Source sequence(s)

BC055258

UniProtKB/TrEMBL

A0A8M1PE81, Q7SXS9

Conserved Domains (2) summary

COG1716
Location:29 → 107

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:25 → 124

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...