AGL6 AGAMOUS-like 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: AGL6
Gene description: AGAMOUS-like 6
Primary source: Araport:AT2G45650
Locus tag: AT2G45650
See related: TAIR:AT2G45650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AGAMOUS-like 6; F17K2.18; REDUCED SHOOT BRANCHING 1; RSB1
Summary: Sequence suggests this encodes a MADS-box transcription factor. Negatively regulates the FLC/MAF clade genes and positively regulates FT in Arabidopsis.
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Genomic context

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See AGL6 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 8

Sequence:: Chromosome: 2; NC_003071.7 (18804190..18806586)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The AGL6-ELF3-FT circuit controls flowering time in Arabidopsis.
Title: The AGL6-ELF3-FT circuit controls flowering time in Arabidopsis.
a function of AGAMOUS-LIKE6 in axillary bud formation in Arabidopsis
Title: Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in Arabidopsis.
agamous-like 6 plays a potential role in the regulation of the circadian clock by regulating zeitlupe mRNA level in Arabidopsis
Title: A genetic screen for leaf movement mutants identifies a potential role for AGAMOUS-LIKE 6 (AGL6) in circadian-clock control.
Results suggest that AGL6 acts as a floral promoter with a dual role, the inhibition of the transcription of the FLC/MAF genes and the promotion of FT expression in Arabidopsis.
Title: AGAMOUS-LIKE 6 is a floral promoter that negatively regulates the FLC/MAF clade genes and positively regulates FT in Arabidopsis.
Early flowering and developmental defects are caused by overexpression of AGL6.
Title: Control of lateral organ development and flowering time by the Arabidopsis thaliana MADS-box Gene AGAMOUS-LIKE6.
AGL6 and AGL13 are regulated through complex interactions of enhancer and silencer elements located in both the 5'-upstream regions and the large first introns.
Title: Intronic regulatory elements determine the divergent expression patterns of AGAMOUS-LIKE6 subfamily members in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_130127.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within floral organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: AGAMOUS-like 6

NP_182089.1

AGAMOUS-like 6 (AGL6); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: vegetative to reproductive phase transition of meristem, floral organ development; LOCATED IN: nucleus; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: C globular stage, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: AGAMOUS-like 13 (TAIR:AT3G61120.1); Has 7294 Blast hits to 7293 proteins in 914 species: Archae - 0; Bacteria - 0; Metazoa - 630; Fungi - 307; Plants - 6281; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18804190..18806586

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130127.2 → NP_182089.1 AGAMOUS-like 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_182089.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29386

UniProtKB/TrEMBL

A0A5S9X7Z8, A0A654F284, A0MET6, I7EL34, I7FEX2, Q1PEU3

Conserved Domains (2) summary

cd00265
Location:2 → 72

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam01486
Location:87 → 171

K-box; K-box region