Prxl2a peroxiredoxin like 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prxl2aprovided by MGI
Official Full Name: peroxiredoxin like 2Aprovided by MGI
Primary source: MGI:MGI:1917814
See related: Ensembl:ENSMUSG00000021792 AllianceGenome:MGI:1917814
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adrx; Pamm; Fam213a; 5730469M10Rik
Summary: Predicted to enable antioxidant activity. Predicted to be involved in regulation of osteoclast differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; ganglia; lung; sensory organ; and urinary system. Orthologous to human PRXL2A (peroxiredoxin like 2A). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in liver E18 (RPKM 29.4), cerebellum adult (RPKM 24.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 22.36 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (40715692..40735790, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (40993735..41013833, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that adipocyte-derived PAMM may suppress macrophage activation by inhibiting MAPK signalling pathway.
Title: Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling.
The PAMM is a redox regulatory protein that modulates osteoclast differentiation in vitro. PAMM expression may affect bone resorption in vivo and help to maintain bone mass.
Title: PAMM: a redox regulatory protein that modulates osteoclast differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antioxidant activity	IBA Inferred from Biological aspect of Ancestor more info
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-like 2A

Names: Adiporedoxin; UPF0765 protein C10orf58 homolog; family with sequence similarity 213, member A; peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; redox-regulatory protein FAM213A; redox-regulatory protein PAMM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316732.1 → NP_001303661.1 peroxiredoxin-like 2A isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC154597, AI840708, AK017688, CN690987, CX238562

UniProtKB/TrEMBL

D3Z252

Conserved Domains (1) summary

cd02970
Location:51 → 204

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001316733.1 → NP_001303662.1 peroxiredoxin-like 2A isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC154597, AI840708, AK017688, BY230987, CX238562

UniProtKB/TrEMBL

D3Z252

Conserved Domains (1) summary

cd02970
Location:51 → 204

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001316734.1 → NP_001303663.1 peroxiredoxin-like 2A isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).

Source sequence(s)

AC154597, AI840708, AK017688, BY075270, CX238562

Consensus CDS

CCDS84116.1

UniProtKB/TrEMBL

D3Z252, Q3U125

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001316735.1 → NP_001303664.1 peroxiredoxin-like 2A isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).

Source sequence(s)

AC154597, AI840708, AK017688, CX238562

Consensus CDS

CCDS84116.1

UniProtKB/TrEMBL

D3Z252, Q3U125

Related

ENSMUSP00000112377.2, ENSMUST00000118466.8

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001316736.1 → NP_001303665.1 peroxiredoxin-like 2A isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).

Source sequence(s)

AC154597, AI840708, AK017688, BY226409, CX238562, W97644

Consensus CDS

CCDS84116.1

UniProtKB/TrEMBL

D3Z252, Q3U125

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001316737.1 → NP_001303666.1 peroxiredoxin-like 2A isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 6, 7, and 8 all encode the same isoform (c).

Source sequence(s)

AC154597, AI840708, AK017688, BY286698, CX238562

Consensus CDS

CCDS26957.1

UniProtKB/Swiss-Prot

Q9CYH2

UniProtKB/TrEMBL

D3Z252

Conserved Domains (1) summary

cd02970
Location:37 → 190

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001316739.1 → NP_001303668.1 peroxiredoxin-like 2A isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 6, 7, and 8 all encode the same isoform (c).

Source sequence(s)

AC154597, AI840708, AK017688, CX238562, W97644

Consensus CDS

CCDS26957.1

UniProtKB/Swiss-Prot

Q9CYH2

UniProtKB/TrEMBL

D3Z252

Related

ENSMUSP00000122866.2, ENSMUST00000130166.8

Conserved Domains (1) summary

cd02970
Location:37 → 190

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001316740.1 → NP_001303669.1 peroxiredoxin-like 2A isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC154597, AI840708, AK017688, BY140069, CX238562

UniProtKB/TrEMBL

D3Z252

Conserved Domains (1) summary

cd02970
Location:44 → 197

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001378813.1 → NP_001365742.1 peroxiredoxin-like 2A isoform b

Status: VALIDATED

Source sequence(s)

AC154597

UniProtKB/TrEMBL

D3Z252, Q3U125

Related

ENSMUSP00000121795.2, ENSMUST00000136661.8

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001378814.1 → NP_001365743.1 peroxiredoxin-like 2A isoform b

Status: VALIDATED

Source sequence(s)

AC154597

UniProtKB/TrEMBL

D3Z252, Q3U125

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001378815.1 → NP_001365744.1 peroxiredoxin-like 2A isoform c

Status: VALIDATED

Source sequence(s)

AC154597

UniProtKB/Swiss-Prot

Q9CYH2

UniProtKB/TrEMBL

D3Z252

Conserved Domains (1) summary

cd02970
Location:37 → 190

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_027464.4 → NP_081740.2 peroxiredoxin-like 2A isoform c

See identical proteins and their annotated locations for NP_081740.2

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 6, 7, and 8 all encode the same isoform (c).

Source sequence(s)

AC154597, AI840708, AK017688, BB851890, CX238562

Consensus CDS

CCDS26957.1

UniProtKB/Swiss-Prot

Q9CYH2

UniProtKB/TrEMBL

D3Z252

Related

ENSMUSP00000022317.9, ENSMUST00000022317.15

Conserved Domains (1) summary

cd02970
Location:37 → 190

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...