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    Mgll monoglyceride lipase [ Mus musculus (house mouse) ]

    Gene ID: 23945, updated on 12-Nov-2024

    Summary

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    Official Symbol
    Mgllprovided by MGI
    Official Full Name
    monoglyceride lipaseprovided by MGI
    Primary source
    MGI:MGI:1346042
    See related
    Ensembl:ENSMUSG00000033174 AllianceGenome:MGI:1346042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mgl; Magl
    Summary
    This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 221.3), genital fat pad adult (RPKM 144.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mgll in Genome Data Viewer
    Location:
    6 D1; 6 39.51 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88701397..88805342)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88724412..88828360)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit alpha 1 Neighboring gene kelch repeat and BTB (POZ) domain containing 12 Neighboring gene STARR-seq mESC enhancer starr_16585 Neighboring gene predicted gene, 26588 Neighboring gene STARR-positive B cell enhancer ABC_E10390 Neighboring gene predicted gene 15612 Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene podocalyxin-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. Kienzl M, et al. Oncoimmunology, 2021. PMID 34527428, Free PMC Article
    2. Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord. Horváth E, et al. Eur J Neurosci, 2014 Feb. PMID 24494682, Free PMC Article
    3. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. Petrenko AB, et al. Behav Brain Res, 2014 Sep 1. PMID 24906199
    4. Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. Martínez-Torres S, et al. Brain Behav Immun, 2019 Oct. PMID 31251974
    5. Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Chen R, et al. Cell Rep, 2012 Nov 29. PMID 23122958, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity.
      Title: MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity.
    2. Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles.
      Title: Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles.
    3. MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain.
      Title: MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain.
    4. Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice.
      Title: Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice.
    5. The Novel Monoacylglycerol Lipase Inhibitor MJN110 Suppresses Neuroinflammation, Normalizes Synaptic Composition and Improves Behavioral Performance in the Repetitive Traumatic Brain Injury Mouse Model.
      Title: The Novel Monoacylglycerol Lipase Inhibitor MJN110 Suppresses Neuroinflammation, Normalizes Synaptic Composition and Improves Behavioral Performance in the Repetitive Traumatic Brain Injury Mouse Model.
    6. Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein.
      Title: Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein.
    7. Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
      Title: Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
    8. Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota.
      Title: Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota.
    9. Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
      Title: Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
    10. Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice.
      Title: Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoacylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in acylglycerol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in acylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in arachidonate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoacylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoacylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocannabinoid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cerebellar climbing fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cerebellar climbing fiber to Purkinje cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in varicosity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monoglyceride lipase
    Names
    monoacylglycerol lipase
    NP_001159721.1
    NP_001159722.1
    NP_001159723.1
    NP_001397462.1
    NP_001397463.1
    NP_001397464.1
    NP_001397465.1
    NP_001397466.1
    NP_035974.1
    XP_036021993.1
    XP_036021995.1
    XP_036021996.1
    XP_036021997.1
    XP_036021998.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166249.2 → NP_001159721.1  monoglyceride lipase isoform c

      See identical proteins and their annotated locations for NP_001159721.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC153860, AC153923
      Consensus CDS
      CCDS51844.1
      UniProtKB/TrEMBL
      Q3UFN1
      Related
      ENSMUSP00000109212.2, ENSMUST00000113582.8
      Conserved Domains (2) summary
      pfam12146
      Location:41 → 230
      Hydrolase_4; Serine aminopeptidase, S33
      cl21494
      Location:22 → 249
      Abhydrolase; alpha/beta hydrolases

    2. NM_001166250.2 → NP_001159722.1  monoglyceride lipase isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (d), which does not have in vivo support, has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC153860
      UniProtKB/Swiss-Prot
      O35678
      Conserved Domains (1) summary
      cl21494
      Location:38 → 93
      Abhydrolase; alpha/beta hydrolases

    3. NM_001166251.2 → NP_001159723.1  monoglyceride lipase isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AC153860, AC153923
      Consensus CDS
      CCDS51843.1
      UniProtKB/TrEMBL
      E9Q3B9, Q3UFX6
      Related
      ENSMUSP00000127374.2, ENSMUST00000163271.8
      Conserved Domains (2) summary
      pfam12146
      Location:57 → 291
      Hydrolase_4; Serine aminopeptidase, S33
      cl21494
      Location:38 → 310
      Abhydrolase; alpha/beta hydrolases

    4. NM_001410533.1 → NP_001397462.1  monoglyceride lipase isoform e

      Status: REVIEWED

      Source sequence(s)
      AC153860, AC153923
      UniProtKB/TrEMBL
      D3YYS6
      Related
      ENSMUSP00000109211.2, ENSMUST00000113581.8

    5. NM_001410534.1 → NP_001397463.1  monoglyceride lipase isoform f

      Status: REVIEWED

      Source sequence(s)
      AC153860, AC153923

    6. NM_001410535.1 → NP_001397464.1  monoglyceride lipase isoform g

      Status: REVIEWED

      Source sequence(s)
      AC153860, AC153923

    7. NM_001410536.1 → NP_001397465.1  monoglyceride lipase isoform h

      Status: REVIEWED

      Source sequence(s)
      AC153860, AC153923

    8. NM_001410537.1 → NP_001397466.1  monoglyceride lipase isoform i

      Status: REVIEWED

      Source sequence(s)
      AC153860
      Related
      ENSMUSP00000145068.2, ENSMUST00000150180.4

    9. NM_011844.5 → NP_035974.1  monoglyceride lipase isoform b

      See identical proteins and their annotated locations for NP_035974.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC153860, AC153923
      Consensus CDS
      CCDS20338.1
      UniProtKB/Swiss-Prot
      O35678, Q3V2R0, Q9D9G8
      UniProtKB/TrEMBL
      Q3UFX6
      Related
      ENSMUSP00000109215.3, ENSMUST00000113585.9
      Conserved Domains (2) summary
      pfam12146
      Location:41 → 275
      Hydrolase_4; Serine aminopeptidase, S33
      cl21494
      Location:22 → 294
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      88701397..88805342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166100.1 → XP_036021993.1  monoglyceride lipase isoform X1

      UniProtKB/TrEMBL
      Q3UFX6
      Conserved Domains (1) summary
      cl21494
      Location:38 → 338
      Abhydrolase; alpha/beta hydrolases

    2. XM_036166104.1 → XP_036021997.1  monoglyceride lipase isoform X5

      Conserved Domains (1) summary
      cl21494
      Location:10 → 262
      Abhydrolase; alpha/beta hydrolases

    3. XM_036166103.1 → XP_036021996.1  monoglyceride lipase isoform X4

      Conserved Domains (1) summary
      cl21494
      Location:10 → 290
      Abhydrolase; alpha/beta hydrolases

    4. XM_036166105.1 → XP_036021998.1  monoglyceride lipase isoform X6

      Conserved Domains (1) summary
      cl21494
      Location:2 → 231
      Abhydrolase; alpha/beta hydrolases

    5. XM_036166102.1 → XP_036021995.1  monoglyceride lipase isoform X3

      Conserved Domains (1) summary
      cl21494
      Location:13 → 293
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35678.1 GenPept UniProtKB/Swiss-Prot:O35678

    Gene LinkOut

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