U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    exoS exoenzyme S [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879837, updated on 11-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    exoS
    Gene description
    exoenzyme S
    Locus tag
    PA3841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_002516.2 (4303141..4304502, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene sodium:sulfate symporter Neighboring gene SAM-dependent methyltransferase Neighboring gene chaperone Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Pseudomonas aeruginosa survives in epithelia by ExoS-mediated inhibition of autophagy and mTOR. Rao L, et al. EMBO Rep, 2021 Feb 3. PMID 33345425, Free PMC Article
    2. Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS. Zhang Y, et al. Cell Microbiol, 2007 Sep. PMID 17490406
    3. ExoS controls the cell contact-mediated switch to effector secretion in Pseudomonas aeruginosa. Cisz M, et al. J Bacteriol, 2008 Apr. PMID 18039770, Free PMC Article
    4. Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins. Yasmin L, et al. Biochem J, 2010 Mar 29. PMID 20144150, Free PMC Article
    5. The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells. Angus AA, et al. Infect Immun, 2010 Nov. PMID 20732998, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.
      Title: Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.
    2. Pseudomonas aeruginosa survives in epithelia by ExoS-mediated inhibition of autophagy and mTOR.
      Title: Pseudomonas aeruginosa survives in epithelia by ExoS-mediated inhibition of autophagy and mTOR.
    3. High frequency of the exoU+/exoS+ genotype associated with multidrug-resistant ""high-risk clones"" of Pseudomonas aeruginosa clinical isolates from Peruvian hospitals.
      Title: High frequency of the exoU+/exoS+ genotype associated with multidrug-resistant "high-risk clones" of Pseudomonas aeruginosa clinical isolates from Peruvian hospitals.
    4. Data provide compelling evidence showing that ExoS/GAP domain is necessary and sufficient to cause intrinsic (mitochondrial) apoptosis. While the low-level of ExoS-induced cytotoxicity that occurs early (within 5 h post-infection) is primarily due to the ADPRT domain activity, the GAP domain is a major contributor to ExoS-induced apoptosis at later time (15-20 h) when ExoS-induced cytotoxicity reaches its maximum level.
      Title: Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity.
    5. Epithelial cell lysates induce exoS and exoT gene transcription in P. aeruginosa PAO1.
      Title: Epithelial cell lysates induce ExoS expression and secretion by Pseudomonas aeruginosa.
    6. Inhibition of internalization of Pseudomonas aeruginosa was associated with T3SS hyperinducibility and ExoS activity.
      Title: The Impact of ExoS on Pseudomonas aeruginosa Internalization by Epithelial Cells Is Independent of fleQ and Correlates with Bistability of Type Three Secretion System Gene Expression.
    7. e present an optimized method to screen for inhibitors of ExoS activity that is amenable to high-throughput format and an intermediate affinity inhibitor that can serve both as assay control and as a starting point for further development
      Title: Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.
    8. We conclude that the ADPRT activity of ExoS acts upon type I pneumocytes to disrupt the pulmonary-vascular barrier during P. aeruginosa pneumonia, leading to bacterial dissemination.
      Title: The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia.
    9. P. aeruginosa injects ExoS into cells through the function of type IV pili
      Title: Pseudomonas aeruginosa injects type III effector ExoS into epithelial cells through the function of type IV pili.
    10. Studied the ExoS to identify unknown cellular targets associated with ExoS-induced cytotoxicity in a P. aeruginosa infection model.A pull-down assay revealed that ExoS bound the truncated KIF7 gene encoding the N-terminal domain (residues 1-109) of KIF7.
      Title: ExoS of Pseudomonas aeruginosa binds to a human KIF7 to induce cytotoxicity in cultured human bronchial epithelial cells.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    exoenzyme S
    NP_252530.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      4303141..4304502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252530.1 exoenzyme S [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252530.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q51451, Q93SQ2
      Conserved Domains (1) summary
      COG5585
      Location:7 → 446
      COG5585; NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3XDA1.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials