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    Krt33a keratin 33A [ Mus musculus (house mouse) ]

    Gene ID: 71888, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Krt33aprovided by MGI
    Official Full Name
    keratin 33Aprovided by MGI
    Primary source
    MGI:MGI:1919138
    See related
    Ensembl:ENSMUSG00000035592 AllianceGenome:MGI:1919138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310015J09Rik
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Orthologous to human KRT31 (keratin 31); KRT33A (keratin 33A); and KRT34 (keratin 34). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Krt33a in Genome Data Viewer
    Location:
    11 D; 11 63.35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99902025..99907038, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100011199..100016212, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin associated protein 16-1 Neighboring gene keratin associated protein 17-1 Neighboring gene STARR-seq mESC enhancer starr_30710 Neighboring gene keratin 33B Neighboring gene keratin 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Fleger-Weckmann A, et al. Matrix Biol, 2016 Dec. PMID 27234308
    2. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article
    3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (3) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cuticular Ha3-I
    Names
    K33A
    hair keratin, type I Ha3-I
    ortholog of keratin, hair, acidic, 3A KRTHA3A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027983.3 → NP_082259.2  keratin, type I cuticular Ha3-I

      See identical proteins and their annotated locations for NP_082259.2

      Status: VALIDATED

      Source sequence(s)
      AK037251
      Consensus CDS
      CCDS25403.1
      UniProtKB/Swiss-Prot
      Q8K0Y2, Q9D7C4
      Related
      ENSMUSP00000018399.3, ENSMUST00000018399.3
      Conserved Domains (2) summary
      COG3352
      Location:252 → 363
      FlaC; Archaellum component FlaC [Cell motility]
      pfam00038
      Location:55 → 366
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99902025..99907038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0Y2.1 GenPept UniProtKB/Swiss-Prot:Q8K0Y2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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