Mapk1 mitogen-activated protein kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk1provided by MGI
Official Full Name: mitogen-activated protein kinase 1provided by MGI
Primary source: MGI:MGI:1346858
See related: Ensembl:ENSMUSG00000063358 AllianceGenome:MGI:1346858
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERK; Erk2; MAPK2; PRKM2; Prkm1; p41mapk; p42mapk; 9030612K14Rik
Summary: Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; embryonic organ development; and respiratory system development. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 10.53 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (16801246..16865317)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (16983382..17047453)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy.
Title: Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy.
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
Title: Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
IL-17A deficiency alleviates cerebral ischemia-reperfusion injury via activating ERK/MAPK pathway in hippocampal CA1 region.
Title: IL-17A deficiency alleviates cerebral ischemia-reperfusion injury via activating ERK/MAPK pathway in hippocampal CA1 region.
Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway.
Title: Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway.
CircMAPK1 promoted CD8 + T cell infiltration in LUAD by improving the IGF2BP1 dependent CCL5 upregulation.
Title: CircMAPK1 promoted CD8 + T cell infiltration in LUAD by improving the IGF2BP1 dependent CCL5 upregulation.
miR-4529-3p Promotes the Progression of Retinoblastoma by Inhibiting RB1 Expression and Activating the ERK Signaling Pathway.
Title: miR-4529-3p Promotes the Progression of Retinoblastoma by Inhibiting RB1 Expression and Activating the ERK Signaling Pathway.
MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism.
Title: MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism.
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Title: BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway.
Title: Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway.
Regulation of ERK2 activity by dynamic S-acylation.
Title: Regulation of ERK2 activity by dynamic S-acylation.

Submit: New GeneRIF Correction See all GeneRIFs (625)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW742788 (e-PCR)
- UniSTS:209170

RH136232 (e-PCR)
- UniSTS:210226

Mapk1 (e-PCR), detects polymorphism
- UniSTS:469816

Mapk3 (e-PCR), detects polymorphism
- UniSTS:469817

01.mHAa9f1.seq (e-PCR)
- UniSTS:122684

RH133391 (e-PCR)
- UniSTS:216674

X58712 (e-PCR)
- UniSTS:125809

NoName (e-PCR)
- UniSTS:237445

RH125652 (e-PCR)
- UniSTS:162438

Mapk1 (e-PCR), detects polymorphism
- UniSTS:507051

Mapk1 (e-PCR), detects polymorphism
- UniSTS:143824

Mapk1 (e-PCR), detects polymorphism
- UniSTS:143825

RH126332 (e-PCR)
- UniSTS:163040

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Bergmann glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in ERBB signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB2-ERBB3 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac neural crest cell development involved in heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in caveolin-mediated endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cytosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in decidualization	ISO Inferred from Sequence Orthology more info
involved_in diadenosine tetraphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within face development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within outer ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of macrophage proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in progesterone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in progesterone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of Golgi inheritance	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of cellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of early endosome to late endosome transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stress-activated MAPK cascade	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to epidermal growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to epidermal growth factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nicotine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thyroid gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within trachea formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	TAS Traceable Author Statement more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early endosome	TAS Traceable Author Statement more info	PubMed
located_in focal adhesion	TAS Traceable Author Statement more info	PubMed
located_in late endosome	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase 1

Names: ERK-2; ERT1; MAP kinase 1; MAP kinase 2; MAPK 1; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 2; p42-MAPK

NP_001033752.1

EC 2.7.11.24

NP_001344044.1

EC 2.7.11.24

NP_036079.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038663.1 → NP_001033752.1 mitogen-activated protein kinase 1

See identical proteins and their annotated locations for NP_001033752.1

Status: VALIDATED

Source sequence(s)

BB648734, D10939

Consensus CDS

CCDS27992.1

UniProtKB/Swiss-Prot

P27703, P63085, Q3V1U6

UniProtKB/TrEMBL

Q3UF82

Related

ENSMUSP00000111396.2, ENSMUST00000115731.10

Conserved Domains (1) summary

cd07849
Location:17 → 351

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_001357115.1 → NP_001344044.1 mitogen-activated protein kinase 1

Status: VALIDATED

Source sequence(s)

AC166346, AC166832

Consensus CDS

CCDS27992.1

UniProtKB/Swiss-Prot

P27703, P63085, Q3V1U6

UniProtKB/TrEMBL

Q3UF82

Related

ENSMUSP00000156154.2, ENSMUST00000232611.2

Conserved Domains (1) summary

cd07849
Location:17 → 351

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_011949.3 → NP_036079.1 mitogen-activated protein kinase 1

See identical proteins and their annotated locations for NP_036079.1

Status: VALIDATED

Source sequence(s)

AC154667, AK132241, BB648734

Consensus CDS

CCDS27992.1

UniProtKB/Swiss-Prot

P27703, P63085, Q3V1U6

UniProtKB/TrEMBL

Q3UF82

Related

ENSMUSP00000065983.8, ENSMUST00000069107.14

Conserved Domains (1) summary

cd07849
Location:17 → 351

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

16801246..16865317

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028991.1: Suppressed sequence

Description

NM_028991.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.