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    SLC34A2 solute carrier family 34 member 2 [ Homo sapiens (human) ]

    Gene ID: 10568, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SLC34A2provided by HGNC
    Official Full Name
    solute carrier family 34 member 2provided by HGNC
    Primary source
    HGNC:HGNC:11020
    See related
    Ensembl:ENSG00000157765 MIM:604217; AllianceGenome:HGNC:11020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PULAM; NPTIIb; NaPi2b; NAPI-3B; NAPI-IIb
    Summary
    The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
    Expression
    Restricted expression toward lung (RPKM 380.9) See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC34A2 in Genome Data Viewer
    Location:
    4p15.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (25655851..25678748)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (25637821..25660720)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25657473..25680370)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25621229-25621730 Neighboring gene S-phase kinase associated protein 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr4:25647409-25647582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25656923-25657836 Neighboring gene ribosomal protein S29 pseudogene 11 Neighboring gene SLIRP. pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SLC34A2 as a novel marker for diagnosis and targeted therapy of breast cancer. Chen DR, et al. Anticancer Res, 2010 Oct. PMID 21036732
    2. Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activity. Ye W, et al. Cell Death Dis, 2017 Feb 2. PMID 28151475, Free PMC Article
    3. The effects and mechanisms of SLC34A2 on tumorigenicity in human non-small cell lung cancer stem cells. Jiang Z, et al. Tumour Biol, 2016 Aug. PMID 26846105
    4. The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer. Wang Y, et al. J Biomed Sci, 2015 Jul 9. PMID 26156586, Free PMC Article
    5. Elevated expression of SLC34A2 inhibits the viability and invasion of A549 cells. Yang W, et al. Mol Med Rep, 2014 Sep. PMID 25017204, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.
      Title: SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.
    2. New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review.
      Title: New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review.
    3. Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis.
      Title: Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis.
    4. Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases.
      Title: Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases.
    5. Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis.
      Title: Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis.
    6. SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms.
      Title: SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms.
    7. Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer.
      Title: Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer.
    8. Findings suggest that solute carrier 34 A2 (SLC34A2) might be a potential therapeutic target for the therapy of glioma patients.
      Title: Knockdown of SLC34A2 inhibits cell proliferation, metastasis, and elevates chemosensitivity in glioma.
    9. he SLC34A2-ROS-HIF-1-induced overexpression of EZH2 promotes colorectal cancer (CRC) cells proliferation and chemo-resistance to apoptosis. SLC34A2-ROS-HIF-1-EZH2 signaling pathway might serve as a novel therapeutic target against CRC.
      Title: The SLC34A2-ROS-HIF-1-induced up-regulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer.
    10. The results demonstrate that miR-25/Gsk3beta-mediated activation of Wnt signaling is responsible for SLC34A2-induced enhancement of neuroblastoma cell stemness.
      Title: SLC34A2 promotes neuroblastoma cell stemness via enhancement of miR-25/Gsk3β-mediated activation of Wnt/β-catenin signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    PULMONARY ALVEOLAR MICROLITHIASIS
    MedGen: C0155912 OMIM: 265100 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90534

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphate ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:phosphate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:phosphate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:phosphate symporter activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular phosphate ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular phosphate ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphate ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-dependent phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in brush border IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in vesicle HDA PubMed 
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent phosphate transport protein 2B
    Names
    sodium/phosphate cotransporter 2B
    solute carrier family 34 (sodium phosphate), member 2
    solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
    type II sodium-dependent phosphate transporter 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021185.2 RefSeqGene

      Range
      5002..27899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177998.2 → NP_001171469.2  sodium-dependent phosphate transport protein 2B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC092436
      Consensus CDS
      CCDS54750.1
      UniProtKB/TrEMBL
      A8K9G0
      Related
      ENSP00000425501.1, ENST00000504570.5
      Conserved Domains (1) summary
      TIGR01013
      Location:104 → 603
      2a58; Phosphate:Na+ Symporter (PNaS) Family

    2. NM_001177999.2 → NP_001171470.2  sodium-dependent phosphate transport protein 2B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC092436
      Consensus CDS
      CCDS54750.1
      UniProtKB/TrEMBL
      A8K9G0
      Related
      ENSP00000423021.1, ENST00000503434.5
      Conserved Domains (1) summary
      TIGR01013
      Location:104 → 603
      2a58; Phosphate:Na+ Symporter (PNaS) Family

    3. NM_006424.3 → NP_006415.3  sodium-dependent phosphate transport protein 2B isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC092436
      Consensus CDS
      CCDS3435.1
      UniProtKB/Swiss-Prot
      A5PL17, O95436, Q8N2K2, Q8WYA9, Q9P0V7
      UniProtKB/TrEMBL
      A0A0B5E3E9
      Related
      ENSP00000371483.3, ENST00000382051.8
      Conserved Domains (1) summary
      TIGR01013
      Location:105 → 604
      2a58; Phosphate:Na+ Symporter (PNaS) Family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      25655851..25678748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      25637821..25660720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95436.3 GenPept UniProtKB/Swiss-Prot:O95436

    Gene LinkOut

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