Nr2f2 nuclear receptor subfamily 2, group F, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr2f2provided by MGI
Official Full Name: nuclear receptor subfamily 2, group F, member 2provided by MGI
Primary source: MGI:MGI:1352452
See related: Ensembl:ENSMUSG00000030551 AllianceGenome:MGI:1352452
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EAR3; ARP-1; SVP40; Aporp1; COUPTFB; COUP-TF2; Tcfcoup2; COUP-TFII; 2700033K02Rik; 9430015G03Rik
Summary: Enables sequence-specific DNA binding activity. Involved in lymph vessel development. Acts upstream of or within several processes, including blood vessel development; nervous system development; and regionalization. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diaphragmatic hernia and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 38.4), adrenal adult (RPKM 29.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 C; 7 38.66 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (70001694..70016494, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (70351946..70366746, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian follicular development: insights into polycystic ovary syndrome?
Title: Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian follicular development: insights into polycystic ovary syndrome?†.
NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence.
Title: NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence.
hsa_circ_0037722 Drives Keloid Formation by Interacting with miR-140-3p and NR2F2.
Title: hsa_circ_0037722 Drives Keloid Formation by Interacting with miR-140-3p and NR2F2.
Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti-Mullerian hormone receptor type 2 transcription in mouse MA-10 Leydig cells.
Title: Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti-Müllerian hormone receptor type 2 transcription in mouse MA-10 Leydig cells.
Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1alpha Signaling in Diabetes-Induced Heart Failure Mice.
Title: Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1α Signaling in Diabetes-Induced Heart Failure Mice.
Isoforms of the orphan nuclear receptor COUPTFII differentially modulate pancreatic cancer progression.
Title: Isoforms of the orphan nuclear receptor COUP‑TFII differentially modulate pancreatic cancer progression.
Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cellsdagger.
Title: Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†.
Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis.
Title: Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis.
Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury.
Title: Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury.
Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2.
Title: Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NR2F2_2074 (e-PCR)
- UniSTS:280878

PMC316637P1 (e-PCR)
- UniSTS:273023

X76653 (e-PCR)
- UniSTS:125850

D1Bda25 (e-PCR)
- UniSTS:239772

Nr2f2 (e-PCR), detects polymorphism
- UniSTS:186525

NoName (e-PCR)
- UniSTS:235685

NoName (e-PCR)
- UniSTS:235687

Nr2f2 (e-PCR), detects polymorphism
- UniSTS:536537

D7S2770 (e-PCR)
- UniSTS:17115

Nr2f2 (e-PCR), detects polymorphism
- UniSTS:507101

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in female gonad development	ISO Inferred from Sequence Orthology more info
involved_in female gonad development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interneuron migration	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lymph vessel development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lymphatic endothelial cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in lymphatic endothelial cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maternal placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within placenta blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within radial pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COUP transcription factor 2

Names: COUP transcription factor II; COUP-TF II; apolipoprotein AI regulatory protein 1; apolipoprotein regulatory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009697.3 → NP_033827.2 COUP transcription factor 2 isoform 1

See identical proteins and their annotated locations for NP_033827.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AC125317, BC042484, BC094360

Consensus CDS

CCDS21359.1

UniProtKB/Swiss-Prot

P43135, Q60632, Q61438

UniProtKB/TrEMBL

Q3UST6

Related

ENSMUSP00000032768.8, ENSMUST00000032768.15

Conserved Domains (2) summary

cd06948
Location:177 → 411

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:79 → 151

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
NM_183261.3 → NP_899084.2 COUP transcription factor 2 isoform 2

See identical proteins and their annotated locations for NP_899084.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC125317, BC094360, BY001758

Consensus CDS

CCDS21358.1

UniProtKB/TrEMBL

D3YYP4

Related

ENSMUSP00000086993.6, ENSMUST00000089565.6

Conserved Domains (1) summary

cd06948
Location:44 → 278

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

70001694..70016494 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540578.2 → XP_006540641.1 COUP transcription factor 2 isoform X2

See identical proteins and their annotated locations for XP_006540641.1

Conserved Domains (1) summary

cd06948
Location:24 → 258

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
XM_006540577.5 → XP_006540640.1 COUP transcription factor 2 isoform X1

See identical proteins and their annotated locations for XP_006540640.1

Conserved Domains (1) summary

cd06948
Location:34 → 268

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family