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    Lmntd1 lamin tail domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 74071, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lmntd1provided by MGI
    Official Full Name
    lamin tail domain containing 1provided by MGI
    Primary source
    MGI:MGI:1921321
    See related
    Ensembl:ENSMUSG00000054966 AllianceGenome:MGI:1921321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmna1; Ifltd1; Lmna-rs1; 4933403M22Rik
    Summary
    Acts upstream of or within cell population proliferation. Located in cytoplasm and nuclear envelope. Orthologous to human LMNTD1 (lamin tail domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 3.5), heart adult (RPKM 1.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmntd1 in Genome Data Viewer
    Location:
    6 G3; 6 77.37 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145311619..145560045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145389314..145450767, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E692 Neighboring gene STARR-positive B cell enhancer ABC_E2810 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4881 Neighboring gene STARR-seq mESC enhancer starr_17786 Neighboring gene ribosomal protein L7 pseudogene Neighboring gene predicted gene, 38926 Neighboring gene predicted gene, 23498 Neighboring gene predicted gene 15499 Neighboring gene predicted gene, 25373 Neighboring gene tubulin, alpha 3B Neighboring gene predicted gene 15704 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. Wang M, et al. Oncogene, 2005 Mar 10. PMID 15688036
    2. Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines. Galbiati F, et al. Cancer Lett, 2006 Dec 8. PMID 16458428
    3. Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Manenti G, et al. Oncogene, 2004 May 27. PMID 15064703
    4. Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Wang M, et al. Cancer Res, 2003 Jun 15. PMID 12810665
    5. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Liu P, et al. Nat Genet, 2006 Aug. PMID 16862160

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pas1c1(lmna-rs1) is a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation in lung adenoma.
      Title: Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus.
    2. Lmna-rs1 is part of the complex multigenic Pas1 locus. It may be a tumor suppressor. AA changes and downregulation are associated with lung adenoma susceptibility.
      Title: Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lamin tail domain-containing protein 1
    Names
    intermediate filament tail domain containing 1
    intermediate filament tail domain-containing protein 1
    lamin A-related sequence 1
    lamin-A-related sequence 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417808.1 → NP_001404737.1  lamin tail domain-containing protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC153577
      UniProtKB/Swiss-Prot
      Q5UE52, Q9D4C1

    2. NM_001417809.1 → NP_001404738.1  lamin tail domain-containing protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153577

    3. NM_001417810.1 → NP_001404739.1  lamin tail domain-containing protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC153577
      UniProtKB/TrEMBL
      E9Q8Y6
      Related
      ENSMUSP00000107335.2, ENSMUST00000111706.8

    4. NM_001417811.1 → NP_001404740.1  lamin tail domain-containing protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC153577

    5. NM_001417812.1 → NP_001404741.1  lamin tail domain-containing protein 1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC153577

    6. NM_028742.3 → NP_083018.1  lamin tail domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_083018.1

      Status: VALIDATED

      Source sequence(s)
      AC153577
      Consensus CDS
      CCDS20695.1
      UniProtKB/Swiss-Prot
      Q5UE52, Q9D4C1
      Related
      ENSMUSP00000107337.3, ENSMUST00000111708.9
      Conserved Domains (1) summary
      pfam00932
      Location:179 → 284
      LTD; Lamin Tail Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      145311619..145560045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506987.5 → XP_006507050.1  lamin tail domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507050.1

      Conserved Domains (1) summary
      pfam00932
      Location:204 → 309
      LTD; Lamin Tail Domain

    2. XM_036152362.1 → XP_036008255.1  lamin tail domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam00932
      Location:178 → 286
      LTD; Lamin Tail Domain

    3. XM_017321792.3 → XP_017177281.1  lamin tail domain-containing protein 1 isoform X7

      Conserved Domains (1) summary
      pfam00932
      Location:119 → 224
      LTD; Lamin Tail Domain

    4. XM_006506986.5 → XP_006507049.1  lamin tail domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507049.1

      Conserved Domains (1) summary
      pfam00932
      Location:204 → 309
      LTD; Lamin Tail Domain

    5. XM_006506985.5 → XP_006507048.1  lamin tail domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507048.1

      Conserved Domains (1) summary
      pfam00932
      Location:204 → 309
      LTD; Lamin Tail Domain

    6. XM_017321788.3 → XP_017177277.1  lamin tail domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5UE52, Q9D4C1
      Conserved Domains (1) summary
      pfam00932
      Location:179 → 284
      LTD; Lamin Tail Domain

    7. XM_017321790.1 → XP_017177279.1  lamin tail domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      E9Q8Y6, Q8BWL2
      Conserved Domains (1) summary
      pfam00932
      Location:129 → 234
      LTD; Lamin Tail Domain

    8. XM_017321786.1 → XP_017177275.1  lamin tail domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5UE52, Q9D4C1
      Conserved Domains (1) summary
      pfam00932
      Location:179 → 284
      LTD; Lamin Tail Domain

    9. XM_017321784.1 → XP_017177273.1  lamin tail domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5UE52, Q9D4C1
      Conserved Domains (1) summary
      pfam00932
      Location:179 → 284
      LTD; Lamin Tail Domain

    10. XM_036152364.1 → XP_036008257.1  lamin tail domain-containing protein 1 isoform X5

    11. XM_017321783.1 → XP_017177272.1  lamin tail domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5UE52, Q9D4C1
      Conserved Domains (1) summary
      pfam00932
      Location:179 → 284
      LTD; Lamin Tail Domain

    12. XM_017321785.3 → XP_017177274.1  lamin tail domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5UE52, Q9D4C1
      Conserved Domains (1) summary
      pfam00932
      Location:179 → 284
      LTD; Lamin Tail Domain

    13. XM_017321787.1 → XP_017177276.1  lamin tail domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5UE52, Q9D4C1
      Conserved Domains (1) summary
      pfam00932
      Location:179 → 284
      LTD; Lamin Tail Domain

    RNA

    1. XR_004933626.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4C1.1 GenPept UniProtKB/Swiss-Prot:Q9D4C1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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