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    nkcc-1 Solute carrier family 12 member 1 [ Caenorhabditis elegans ]

    Gene ID: 3565648, updated on 12-Jun-2024

    Summary

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    Gene symbol
    nkcc-1
    Gene description
    Solute carrier family 12 member 1
    Locus tag
    CELE_Y37A1C.1
    See related
    AllianceGenome:WB:WBGene00012543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in body wall musculature; intestine; neurons; oocyte; and vulval muscle. Human ortholog(s) of this gene implicated in Bartter disease; Bartter disease type 1; Gitelman syndrome; autosomal dominant nonsyndromic deafness 78; and essential hypertension. Orthologous to human SLC12A1 (solute carrier family 12 member 1); SLC12A2 (solute carrier family 12 member 2); and SLC12A3 (solute carrier family 12 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See nkcc-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (14107720..14124056, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene INSulin related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved switch in response to GABA affects development and behavior of the locomotor circuit of Caenorhabditis elegans. Han B, et al. Genetics, 2015 Apr. PMID 25644702, Free PMC Article
    2. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Ji W, et al. Nat Genet, 2008 May. PMID 18391953, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium:potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Solute carrier family 12 member 1
    NP_001076724.1
    • Confirmed by transcript evidence
    NP_001255788.1
    • Confirmed by transcript evidence
    NP_001255789.1
    • Confirmed by transcript evidence
    NP_001255790.1
    • Partially confirmed by transcript evidence
    NP_001255791.1
    • Confirmed by transcript evidence
    NP_001263812.1
    • Confirmed by transcript evidence
    NP_502704.1
    • Partially confirmed by transcript evidence
    NP_502705.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14107720..14124056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268862.4 → NP_001255791.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESD4
      Conserved Domains (3) summary
      TIGR00930
      Location:141 → 1186
      2a30; K-Cl cotransporter
      pfam03522
      Location:727 → 1186
      SLC12; Solute carrier family 12
      cl00456
      Location:299 → 662
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001276883.3 → NP_001263812.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E912
      Conserved Domains (3) summary
      TIGR00930
      Location:143 → 1188
      2a30; K-Cl cotransporter
      pfam03522
      Location:729 → 1188
      SLC12; Solute carrier family 12
      cl00456
      Location:301 → 664
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001268861.4 → NP_001255790.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESD5
      Conserved Domains (3) summary
      TIGR00930
      Location:165 → 1235
      2a30; K-Cl cotransporter
      pfam03522
      Location:751 → 1235
      SLC12; Solute carrier family 12
      cl00456
      Location:323 → 686
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_001083255.4 → NP_001076724.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEQ4
      Conserved Domains (3) summary
      TIGR00930
      Location:165 → 1210
      2a30; K-Cl cotransporter
      pfam03522
      Location:751 → 1210
      SLC12; Solute carrier family 12
      cl00456
      Location:323 → 686
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. NM_001268859.3 → NP_001255788.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P897
      Conserved Domains (2) summary
      TIGR00930
      Location:1 → 870
      2a30; K-Cl cotransporter
      pfam03522
      Location:411 → 870
      SLC12; Solute carrier family 12

    6. NM_001268860.3 → NP_001255789.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P898
      Conserved Domains (1) summary
      pfam03522
      Location:89 → 548
      SLC12; Solute carrier family 12

    7. NM_070303.2 → NP_502704.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFE5
      Conserved Domains (3) summary
      pfam00324
      Location:249 → 742
      AA_permease; Amino acid permease
      pfam03522
      Location:751 → 886
      SLC12; Solute carrier family 12
      cl00456
      Location:323 → 686
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. NM_070304.1 → NP_502705.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFN5
    Nucleotide Protein
    Heading Accession and Version

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