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    Slc46a3 solute carrier family 46, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 71706, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc46a3provided by MGI
    Official Full Name
    solute carrier family 46, member 3provided by MGI
    Primary source
    MGI:MGI:1918956
    See related
    Ensembl:ENSMUSG00000029650 AllianceGenome:MGI:1918956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200006F02Rik
    Summary
    Enables copper ion transmembrane transporter activity. Involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine. Is active in lysosomal membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human SLC46A3 (solute carrier family 46 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in large intestine adult (RPKM 23.2), small intestine adult (RPKM 22.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc46a3 in Genome Data Viewer
    Location:
    5 G3; 5 87.58 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147812707..147831670, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147875897..147894861, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14883 Neighboring gene predicted gene, 54314 Neighboring gene STARR-positive B cell enhancer ABC_E534 Neighboring gene predicted gene, 35648 Neighboring gene proteasome maturation protein Neighboring gene STARR-seq mESC enhancer starr_14888 Neighboring gene predicted gene, 46943 Neighboring gene STARR-seq mESC enhancer starr_14889 Neighboring gene STARR-seq mESC enhancer starr_14890 Neighboring gene STARR-seq mESC enhancer starr_14891 Neighboring gene microtubule associated tumor suppressor candidate 2 Neighboring gene STARR-seq mESC enhancer starr_14892 Neighboring gene STARR-seq mESC enhancer starr_14893 Neighboring gene predicted gene, 46928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Kim JH, et al. Nat Commun, 2021 Jan 12. PMID 33436590, Free PMC Article
    2. Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity. Bharadwaj R, et al. Immunity, 2023 May 9. PMID 37116499, Free PMC Article
    3. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article
    4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis.
      Title: Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357002.1 → NP_001343931.1  lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC122299, AC133954
      Consensus CDS
      CCDS19880.1
      UniProtKB/Swiss-Prot
      Q9DC26
      Related
      ENSMUSP00000113879.2, ENSMUST00000118527.8
      Conserved Domains (1) summary
      cl28910
      Location:3 → 437
      MFS; Major Facilitator Superfamily

    2. NM_027872.4 → NP_082148.1  lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor

      See identical proteins and their annotated locations for NP_082148.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC122299, AC133954
      Consensus CDS
      CCDS19880.1
      UniProtKB/Swiss-Prot
      Q9DC26
      Related
      ENSMUSP00000031655.4, ENSMUST00000031655.4
      Conserved Domains (1) summary
      cl28910
      Location:3 → 437
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      147812707..147831670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504867.5 → XP_006504930.1  lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 isoform X2

      See identical proteins and their annotated locations for XP_006504930.1

      UniProtKB/Swiss-Prot
      Q9DC26
      Conserved Domains (1) summary
      cl28910
      Location:3 → 437
      MFS; Major Facilitator Superfamily

    2. XM_006504865.4 → XP_006504928.1  lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 isoform X1

      See identical proteins and their annotated locations for XP_006504928.1

      UniProtKB/Swiss-Prot
      Q9DC26
      Conserved Domains (1) summary
      cl28910
      Location:3 → 437
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC26.1 GenPept UniProtKB/Swiss-Prot:Q9DC26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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