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    Tmem25 transmembrane protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 71687, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem25provided by MGI
    Official Full Name
    transmembrane protein 25provided by MGI
    Primary source
    MGI:MGI:1918937
    See related
    Ensembl:ENSMUSG00000002032 AllianceGenome:MGI:1918937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610039J01Rik
    Summary
    Involved in negative regulation of excitatory postsynaptic potential and regulation of protein stability. Located in late endosome and lysosome. Is expressed in basioccipital bone; orbito-sphenoid; and temporal bone petrous part. Orthologous to human TMEM25 (transmembrane protein 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 44.3), liver adult (RPKM 27.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem25 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44705069..44710821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44793772..44799524, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene archain 1 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene intraflagellar transport 46 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene lysine (K)-specific methyltransferase 2A Neighboring gene predicted gene, 39326 Neighboring gene STARR-positive B cell enhancer ABC_E6728 Neighboring gene STARR-seq mESC enhancer starr_23986 Neighboring gene predicted gene, 30883

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression. Bi J, et al. Nat Commun, 2023 Apr 24. PMID 37095176, Free PMC Article
    2. Identification and characterization of human TMEM25 and mouse Tmem25 genes in silico. Katoh M, et al. Oncol Rep, 2004 Aug. PMID 15254712
    3. TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation. Zhang H, et al. J Clin Invest, 2019 Sep 3. PMID 31424425, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression.
      Title: TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression.
    2. These results provide some insights into TMEM25 biology in the brain and the functional relationship between TMEM25 and epilepsy.
      Title: TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of excitatory postsynaptic potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357383.1 → NP_001344312.1  transmembrane protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC142113
      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (1) summary
      cl11960
      Location:51 → 142
      Ig; Immunoglobulin domain

    2. NM_001357384.1 → NP_001344313.1  transmembrane protein 25 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC142113
      Consensus CDS
      CCDS23120.1
      UniProtKB/Swiss-Prot
      Q3TMP3, Q6PAK7, Q9DCF1
      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (2) summary
      cd00096
      Location:30 → 34
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    3. NM_001357385.1 → NP_001344314.1  transmembrane protein 25 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC142113
      Consensus CDS
      CCDS23120.1
      UniProtKB/Swiss-Prot
      Q3TMP3, Q6PAK7, Q9DCF1
      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (2) summary
      cd00096
      Location:30 → 34
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    4. NM_001357386.1 → NP_001344315.1  transmembrane protein 25 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC142113, AK090375, AW457301
      Consensus CDS
      CCDS90554.1
      UniProtKB/TrEMBL
      A0A1N9MYB8
      Related
      ENSMUSP00000110353.3, ENSMUST00000114705.9
      Conserved Domains (2) summary
      cd00096
      Location:30 → 34
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    5. NM_027865.3 → NP_082141.1  transmembrane protein 25 isoform b precursor

      See identical proteins and their annotated locations for NP_082141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AK165199, AW457301
      Consensus CDS
      CCDS23120.1
      UniProtKB/Swiss-Prot
      Q3TMP3, Q6PAK7, Q9DCF1
      UniProtKB/TrEMBL
      Q3U4J4
      Related
      ENSMUSP00000002100.8, ENSMUST00000002100.8
      Conserved Domains (2) summary
      cd00096
      Location:30 → 34
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    RNA

    1. NR_151678.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC142113

    2. NR_151679.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC142113
      Related
      ENSMUST00000132020.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44705069..44710821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244613.1 → XP_030100473.1  transmembrane protein 25 isoform X4

      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (1) summary
      cl11960
      Location:52 → 143
      Ig; Immunoglobulin domain

    2. XM_030244612.1 → XP_030100472.1  transmembrane protein 25 isoform X3

      Conserved Domains (1) summary
      cl11960
      Location:127 → 218
      Ig; Immunoglobulin domain

    3. XM_030244611.1 → XP_030100471.1  transmembrane protein 25 isoform X2

      Conserved Domains (1) summary
      cl11960
      Location:128 → 219
      Ig; Immunoglobulin domain

    4. XM_030244609.1 → XP_030100469.1  transmembrane protein 25 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:128 → 219
      Ig; Immunoglobulin domain

    5. XM_030244614.2 → XP_030100474.1  transmembrane protein 25 isoform X7

      Conserved Domains (1) summary
      cl11960
      Location:51 → 142
      Ig; Immunoglobulin domain

    6. XM_036155294.1 → XP_036011187.1  transmembrane protein 25 isoform X9

    7. XM_036155292.1 → XP_036011185.1  transmembrane protein 25 isoform X6

      Conserved Domains (2) summary
      cd00096
      Location:55 → 59
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:52 → 143
      Ig; Immunoglobulin domain

    8. XM_011242601.3 → XP_011240903.1  transmembrane protein 25 isoform X9

      See identical proteins and their annotated locations for XP_011240903.1

    9. XM_030244615.2 → XP_030100475.1  transmembrane protein 25 isoform X9

    10. XM_036155293.1 → XP_036011186.1  transmembrane protein 25 isoform X8

      UniProtKB/TrEMBL
      A0A1N9MYB8
      Conserved Domains (2) summary
      cd00096
      Location:30 → 34
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    11. XM_006510610.4 → XP_006510673.1  transmembrane protein 25 isoform X5

      See identical proteins and their annotated locations for XP_006510673.1

      UniProtKB/Swiss-Prot
      Q3TMP3, Q6PAK7, Q9DCF1
      UniProtKB/TrEMBL
      Q3U4J4
      Conserved Domains (2) summary
      cd00096
      Location:30 → 34
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    12. XM_036155295.1 → XP_036011188.1  transmembrane protein 25 isoform X9

    13. XM_011242602.1 → XP_011240904.1  transmembrane protein 25 isoform X9

      See identical proteins and their annotated locations for XP_011240904.1

    14. XM_030244616.1 → XP_030100476.1  transmembrane protein 25 isoform X9

    15. XM_011242603.2 → XP_011240905.1  transmembrane protein 25 isoform X9

      See identical proteins and their annotated locations for XP_011240905.1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCF1.1 GenPept UniProtKB/Swiss-Prot:Q9DCF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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