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    Tmprss4 transmembrane protease, serine 4 [ Mus musculus (house mouse) ]

    Gene ID: 214523, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmprss4provided by MGI
    Official Full Name
    transmembrane protease, serine 4provided by MGI
    Primary source
    MGI:MGI:2384877
    See related
    Ensembl:ENSMUSG00000032091 AllianceGenome:MGI:2384877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAP2; mCAP2
    Summary
    Predicted to enable serine-type peptidase activity. Acts upstream of or within response to wounding. Located in secretory granule. Is expressed in alimentary system; olfactory epithelium; and urinary system. Orthologous to human TMPRSS4 (transmembrane serine protease 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 63.2), colon adult (RPKM 50.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmprss4 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45084024..45115417, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45172726..45204119, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sodium channel, type IV, beta Neighboring gene STARR-seq mESC enhancer starr_23992 Neighboring gene predicted gene, 39327 Neighboring gene predicted gene, 57797 Neighboring gene small integral membrane protein 35 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45029701-45030002 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45054121-45054422 Neighboring gene interleukin 10 receptor, alpha Neighboring gene microRNA 7086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45108641-45108750 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene transmembrane protease, serine 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4. Keppner A, et al. PLoS One, 2015. PMID 26309024, Free PMC Article
    2. Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways. Harbig A, et al. J Biol Chem, 2020 Aug 14. PMID 32303635, Free PMC Article
    3. The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases. Kühn N, et al. J Virol, 2016 May. PMID 26889029, Free PMC Article
    4. TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections. Ohler A, et al. Biol Chem, 2012 Sep. PMID 22944691
    5. TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site. Passero CJ, et al. Am J Physiol Renal Physiol, 2012 Jan 1. PMID 21993886, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis.
      Title: Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis.
    2. The lung fibrotic response evaluated at 28 days after bleomycin injury was markedly attenuated in the haplodeficient and deficient TMPRSS4 mice.
      Title: Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury.
    3. Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4
      Title: Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.
    4. Progression and metastatic potential of several cancers is concordant with an increased expression of TMPRSS4.
      Title: TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections.
    5. TMPRSS4 primarily activates ENaC by cleaving basic residues within the tract gammaK173-K186 distal to the furin cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit.
      Title: TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site.
    6. mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC activation
      Title: Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of growth rate ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral entry into host cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protease serine 4
    Names
    channel-activating protease 2
    channel-activating protease 4
    membrane-type serine protease 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364528.1 → NP_001351457.1  transmembrane protease serine 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK078890, EH103381
      Conserved Domains (2) summary
      smart00020
      Location:62 → 287
      Tryp_SPc; Trypsin-like serine protease
      cl02509
      Location:1 → 55
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. NM_145403.3 → NP_663378.1  transmembrane protease serine 4 isoform 1

      See identical proteins and their annotated locations for NP_663378.1

      Status: VALIDATED

      Source sequence(s)
      AC122305, AC166051
      Consensus CDS
      CCDS40607.1
      UniProtKB/Swiss-Prot
      Q8VCA5
      Related
      ENSMUSP00000034599.9, ENSMUST00000034599.15
      Conserved Domains (4) summary
      smart00020
      Location:202 → 427
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:56 → 90
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:203 → 430
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl02509
      Location:106 → 195
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45084024..45115417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313272.1 → XP_017168761.1  transmembrane protease serine 4 isoform X1

      Conserved Domains (2) summary
      smart00020
      Location:62 → 287
      Tryp_SPc; Trypsin-like serine protease
      cl02509
      Location:1 → 55
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCA5.1 GenPept UniProtKB/Swiss-Prot:Q8VCA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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