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    CG3626 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31377, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CG3626provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029706
    Locus tag
    Dmel_CG3626
    See related
    AllianceGenome:FB:FBgn0029706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3626
    Summary
    Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be part of mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex and pyruvate dehydrogenase complex. Predicted to be active in mitochondrial matrix. Is expressed in adult head and spermatozoon. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CG3626 in Genome Data Viewer
    Location:
    4C2-4C2; 1-8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4366417..4371136)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4260450..4265169)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43614 Neighboring gene long non-coding RNA:CR46499 Neighboring gene mir-983-1 stem loop Neighboring gene mir-983-2 stem loop Neighboring gene long non-coding RNA:CR32773 Neighboring gene mir-982 stem loop Neighboring gene mir-303 stem loop Neighboring gene mir-984 stem loop Neighboring gene bifid

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhancer trap infidelity in Drosophila optomotor-blind. Mayer LR, et al. Fly (Austin), 2013 Apr-Jun. PMID 23519069, Free PMC Article
    2. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
    3. Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling. Ermanoska B, et al. Nat Commun, 2023 Mar 8. PMID 36890170, Free PMC Article
    4. Chromosomal distribution of PcG proteins during Drosophila development. Nègre N, et al. PLoS Biol, 2006 Jun. PMID 16613483, Free PMC Article
    5. Testing Implications of the Omnigenic Model for the Genetic Analysis of Loci Identified through Genome-wide Association. Zhang W, et al. Curr Biol, 2021 Mar 8. PMID 33417882

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pyruvate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3626-PA
    NP_572162.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4366417..4371136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131934.2 → NP_572162.2  uncharacterized protein Dmel_CG3626 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572162.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQN6, Q9W4K8
      Related
      FBpp0070620
      Conserved Domains (5) summary
      COG0404
      Location:480 → 908
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01266
      Location:70 → 429
      DAO; FAD dependent oxidoreductase
      pfam01571
      Location:490 → 774
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:783 → 887
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:432 → 487
      FAO_M; FAD dependent oxidoreductase central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQN6 Q8MQN6
    Q9W4K8 Q9W4K8

    Gene LinkOut

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