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    HEF3 translation elongation factor EF-3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855718, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEF3
    Official Full Name
    translation elongation factor EF-3
    Primary source
    SGD:S000004959
    Locus tag
    YNL014W
    See related
    AllianceGenome:SGD:S000004959; FungiDB:YNL014W; VEuPathDB:YNL014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ZRG7
    Summary
    Enables ATP hydrolysis activity and translation elongation factor activity. Involved in translational elongation. Located in cytosolic ribosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HEF3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (606319..609453)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pub1p Neighboring gene Pbi2p Neighboring gene putative carboxylic ester hydrolase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A highly conserved intraspecies homolog of the Saccharomyces cerevisiae elongation factor-3 encoded by the HEF3 gene. Maurice TC, et al. Yeast, 1998 Sep 15. PMID 9778796
    2. Translation elongation factor-3 (EF-3): an evolving eukaryotic ribosomal protein? Belfield GP, et al. J Mol Evol, 1995 Sep. PMID 7563124
    3. Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress. Gościńska K, et al. Genes (Basel), 2020 Nov 28. PMID 33260587, Free PMC Article
    4. Limited proteolysis of yeast elongation factor 3. Sequence and location of the subdomains. Kambampati R, et al. J Biol Chem, 2000 Jun 2. PMID 10747994
    5. Domain structure analysis of elongation factor-3 from Saccharomyces cerevisiae by limited proteolysis and differential scanning calorimetry. Ladror US, et al. Protein Sci, 1998 Dec. PMID 9865954, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.
      Title: Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosolic ribosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation elongation factor EF-3
    NP_014384.3
    • Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      606319..609453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182853.3 → NP_014384.3  TPA: translation elongation factor EF-3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014384.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1G4, P53978
      UniProtKB/TrEMBL
      C7GJF2, N1P4M0
      Conserved Domains (3) summary
      COG0488
      Location:429 → 986
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
      sd00044
      Location:129 → 158
      HEAT; HEAT repeat [structural motif]
      pfam17947
      Location:336 → 411
      4HB; Four helical bundle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53978.2

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