UFE1 Ufe1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Gene symbol: UFE1
Gene description: Ufe1p
Primary source: FungiDB:YOR075W
Locus tag: YOR075W
See related: SGD:S000005601; AllianceGenome:SGD:S000005601; VEuPathDB:YOR075W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable SNAP receptor activity. Involved in endoplasmic reticulum membrane fusion and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum. Part of SNARE complex. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See UFE1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (468212..469252)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An ER-localized SNARE protein UFE1 is exported in specific COPII vesicles for autophagosome biogenesis.
Title: An ER-Localized SNARE Protein Is Exported in Specific COPII Vesicles for Autophagosome Biogenesis.
Data show that the yeast Ufe1 is prone to degradation by an ERAD-like mechanism but is protected against degradation through binding to Sly1, a known SNARE regulator of the Sec1-Munc18 (SM) protein family.
Title: SM-protein-controlled ER-associated degradation discriminates between different SNAREs.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Ufe1p

NP_014718.1

t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

468212..469252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183494.1 → NP_014718.1 TPA: Ufe1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014718.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2D8, P41834

UniProtKB/TrEMBL

A0A8H4F7E7, G2WMV3, N1NYB8

Conserved Domains (3) summary

COG5325
Location:170 → 341

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15850
Location:258 → 316

SNARE_syntaxin18; SNARE motif, subgroup Qa

pfam10496
Location:4 → 90

Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus