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    YVC1 Yvc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854255, updated on 2-Nov-2024

    Summary

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    Official Symbol
    YVC1
    Official Full Name
    Yvc1p
    Primary source
    SGD:S000005613
    Locus tag
    YOR087W
    See related
    AllianceGenome:SGD:S000005613; FungiDB:YOR087W; VEuPathDB:YOR087W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR088W
    Summary
    Enables monoatomic ion channel activity. Involved in calcium ion transmembrane import into cytosol and intracellular monoatomic cation homeostasis. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2C; keratosis (multiple); migraine (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Orthologous to several human genes including TRPV1 (transient receptor potential cation channel subfamily V member 1); TRPV2 (transient receptor potential cation channel subfamily V member 2); and TRPV3 (transient receptor potential cation channel subfamily V member 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See YVC1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (487707..489734)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tricalbin Neighboring gene tRNA-Asn Neighboring gene Rab family GTPase VPS21 Neighboring gene type 2C protein phosphatase PTC5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cation-selective channels in the vacuolar membrane of Saccharomyces: dependence on calcium, redox state, and voltage. Bertl A, et al. Proc Natl Acad Sci U S A, 1990 Oct. PMID 1700419, Free PMC Article
    2. A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane. Palmer CP, et al. Proc Natl Acad Sci U S A, 2001 Jul 3. PMID 11427713, Free PMC Article
    3. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Ahmed T, et al. Structure, 2022 Jan 6. PMID 34453887, Free PMC Article
    4. Heterologously expressed fungal transient receptor potential channels retain mechanosensitivity in vitro and osmotic response in vivo. Zhou XL, et al. Eur Biophys J, 2005 Jul. PMID 15711808
    5. Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate. Zhou X, et al. Proc Natl Acad Sci U S A, 2007 Sep 25. PMID 17878311, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)-calmodulin binding.
      Title: Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)-calmodulin binding.
    2. Data show that Ca(2+) on the lumen side inhibited channel activity of vacuolar cation channel TRPY1 protein (Yvc1 protein).
      Title: In vitro and in vivo characterization of modulation of the vacuolar cation channel TRPY1 from Saccharomyces cerevisiae.
    3. Yvc1p has nine cysteine residues, of which eight are located in the cytoplasmic regions and one on the transmembrane domain. We show that three of these cysteines, Cys-17, Cys-79, and Cys-191, are specifically glutathionylated.
      Title: Glutathione depletion activates the yeast vacuolar transient receptor potential channel, Yvc1p, by reversible glutathionylation of specific cysteines.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane import into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole-mitochondrion membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Yvc1p
    NP_014730.2
    • Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      487707..489734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183506.1 → NP_014730.2  TPA: Yvc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014730.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2E9, Q08500, Q12324, Q7LGN3
      UniProtKB/TrEMBL
      A6ZNT8, B3LJD4, B5VRY3, C7GMP6, N1NVS1
      Conserved Domains (1) summary
      pfam00520
      Location:235 → 470
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12324.2

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