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    DIA2 DNA-binding SCF ubiquitin ligase subunit DIA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854247, updated on 3-Nov-2024

    Summary

    Official Symbol
    DIA2
    Official Full Name
    DNA-binding SCF ubiquitin ligase subunit DIA2
    Primary source
    SGD:S000005606
    Locus tag
    YOR080W
    See related
    AllianceGenome:SGD:S000005606; FungiDB:YOR080W; VEuPathDB:YOR080W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-31
    Summary
    Enables DNA replication origin binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; constitutive heterochromatin formation; and invasive growth in response to glucose limitation. Located in nuclear replication fork. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See DIA2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (474594..476792)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bud21p Neighboring gene Mn(2+) transporter ATX2 Neighboring gene triacylglycerol lipase Neighboring gene transcriptional repressor WHI5

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA-binding SCF ubiquitin ligase subunit DIA2
    NP_014723.2
    • Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      474594..476792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183499.1NP_014723.2  TPA: DNA-binding SCF ubiquitin ligase subunit DIA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014723.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2E3, O00034, Q08496, Q7LGN4
      UniProtKB/TrEMBL
      G2WMV8
      Conserved Domains (4) summary
      sd00033
      Location:483511
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:553581
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00006
      Location:1943
      TPR; TPR repeat [structural motif]
      pfam00646
      Location:209241
      F-box; F-box domain