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    CDC21 thymidylate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854241, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDC21
    Official Full Name
    thymidylate synthase
    Primary source
    SGD:S000005600
    Locus tag
    YOR074C
    See related
    AllianceGenome:SGD:S000005600; FungiDB:YOR074C; VEuPathDB:YOR074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CRT9; TMP1
    Summary
    Enables thymidylate synthase activity. Involved in dTMP biosynthetic process. Located in nuclear periphery. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CDC21 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (466675..467589, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro Neighboring gene Sgo1p Neighboring gene Ufe1p Neighboring gene Ski7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of thymidylate synthase (TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis. Muralidharan N, et al. Clin Rheumatol, 2017 Jun. PMID 28349270
    2. Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence. Brody JR, et al. Cancer Res, 2009 Feb 1. PMID 19155291, Free PMC Article
    3. Thymidylate synthase is localized to the nuclear periphery in the yeast Saccharomyces cerevisiae. Poon PP, et al. J Biol Chem, 1994 Mar 18. PMID 8132557
    4. Isolation of the thymidylate synthetase gene (TMP1) by complementation in Saccharomyces cerevisiae. Taylor GR, et al. Mol Cell Biol, 1982 Apr. PMID 6287238, Free PMC Article
    5. Transcriptional regulation of the cell cycle-dependent thymidylate synthase gene of Saccharomyces cerevisiae. McIntosh EM, et al. Mol Cell Biol, 1988 Nov. PMID 3062362, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 28-bp tandem repeat 3R allele and 6-bp deletion allele (rs34489327) may favor non-response to methotrexate in south Indian Tamils
      Title: Effect of thymidylate synthase (TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dTTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thymidylate synthase
    NP_014717.2
    • Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      466675..467589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183493.1 → NP_014717.2  TPA: thymidylate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014717.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2D7, P06785, Q12694
      UniProtKB/TrEMBL
      B3LJC3, C7GT41, C8ZI35, G2WMV2, N1P314
      Conserved Domains (1) summary
      PTZ00164
      Location:5 → 304
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06785.1

    Gene LinkOut

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