CTA1 catalase A [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CTA1
Official Full Name: catalase A
Primary source: SGD:S000002664
Locus tag: YDR256C
See related: AllianceGenome:SGD:S000002664; FungiDB:YDR256C; VEuPathDB:YDR256C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables catalase activity. Involved in hydrogen peroxide catabolic process and response to reactive oxygen species. Located in mitochondrial matrix and peroxisomal matrix. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CTA1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (968133..969680, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Ile264 amino acid residue in Pex5, which is adjacent to the FxxxW diaromatic domain that was previously shown to be crucial for recognizing AOx and Cat2 as cargos, is also important for the efficient import of Fox2 and Cta1.
Title: The budding yeast Pex5p receptor directs Fox2p and Cta1p into peroxisomes via its N-terminal region near the FxxxW domain.
MET18 deficiency diminished the replicative capacity of yeast cells as evidenced by the shortened replicative lifespan, which can be restored by CTT1 overexpression, but not by CTA1, in the MET18-deficient cells.
Title: MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity.
Ccp1 responds to respiration-derived H2O2 via a previously unidentified mechanism involving H2O2-activated heme transfer to apoCta1
Title: Respiration triggers heme transfer from cytochrome c peroxidase to catalase in yeast mitochondria.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables catalase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catalase activity	IDA Inferred from Direct Assay more info	PubMed
enables catalase activity	IEA Inferred from Electronic Annotation more info
enables catalase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables catalase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catalase A

NP_010542.1

EC 1.11.1.6

Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

968133..969680 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180564.1 → NP_010542.1 TPA: catalase A [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010542.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSN6, E9P947, P15202

UniProtKB/TrEMBL

A6ZYK8, B3LG34, C7GTJ1, C8Z5G8, G2WAZ9, N1P8H9

Conserved Domains (1) summary

cd08157
Location:47 → 502

catalase_fungal; Fungal catalases similar to yeast catalases A and T