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    EAT1 putative hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852898, updated on 2-Nov-2024

    Summary

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    Official Symbol
    EAT1
    Official Full Name
    putative hydrolase
    Primary source
    SGD:S000003247
    Locus tag
    YGR015C
    See related
    AllianceGenome:SGD:S000003247; FungiDB:YGR015C; VEuPathDB:YGR015C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables C-acetyltransferase activity. Predicted to be involved in cellular lipid metabolic process. Located in mitochondrion. Orthologous to human ABHD8 (abhydrolase domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See EAT1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (521090..522076, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Snu71p Neighboring gene Msb2p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ethyl acetate production by the elusive alcohol acetyltransferase from yeast. Kruis AJ, et al. Metab Eng, 2017 May. PMID 28356220
    2. Polygenic Analysis in Absence of Major Effector ATF1 Unveils Novel Components in Yeast Flavor Ester Biosynthesis. Holt S, et al. mBio, 2018 Aug 28. PMID 30154260, Free PMC Article
    3. Contribution of Eat1 and Other Alcohol Acyltransferases to Ester Production in Saccharomyces cerevisiae. Kruis AJ, et al. Front Microbiol, 2018. PMID 30622529, Free PMC Article
    4. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Willingham S, et al. Science, 2003 Dec 5. PMID 14657499
    5. Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress. Jaworek W, et al. J Biol Chem, 2022 Oct. PMID 36115461, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables C-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative hydrolase
    NP_011529.1
    • Ethanol acetyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      521090..522076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181144.1 → NP_011529.1  TPA: putative hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011529.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUF1, P53208
      UniProtKB/TrEMBL
      A6ZV06, B3LIK2, C7GK84, C8Z8Q9, G2WEA7, N1P3E8
      Conserved Domains (1) summary
      pfam00561
      Location:39 → 309
      Abhydrolase_1; alpha/beta hydrolase fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53208.1

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