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    GTT1 bifunctional glutathione transferase/peroxidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854856, updated on 2-Nov-2024

    Summary

    Official Symbol
    GTT1
    Official Full Name
    bifunctional glutathione transferase/peroxidase
    Primary source
    SGD:S000001477
    Locus tag
    YIR038C
    See related
    AllianceGenome:SGD:S000001477; FungiDB:YIR038C; VEuPathDB:YIR038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process and protein glutathionylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See GTT1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (423809..424513, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene sepiapterin reductase family protein IRC24 Neighboring gene peroxiredoxin HYR1 Neighboring gene aspartyl protease Neighboring gene seripauperin PAU15

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein glutathionylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    bifunctional glutathione transferase/peroxidase
    NP_012304.1
    • ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      423809..424513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179560.1NP_012304.1  TPA: bifunctional glutathione transferase/peroxidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012304.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVW9, P40582
      UniProtKB/TrEMBL
      A6ZVV8, B3LTH2, C7GLR8, C8ZAU1, G2WFW6, N1P0S6
      Conserved Domains (2) summary
      cd03189
      Location:93218
      GST_C_GTT1_like; C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases
      cd03046
      Location:687
      GST_N_GTT1_like; GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved ...