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    IRC24 sepiapterin reductase family protein IRC24 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854854, updated on 2-Nov-2024

    Summary

    Official Symbol
    IRC24
    Official Full Name
    sepiapterin reductase family protein IRC24
    Primary source
    SGD:S000001475
    Locus tag
    YIR036C
    See related
    AllianceGenome:SGD:S000001475; FungiDB:YIR036C; VEuPathDB:YIR036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables benzil reductase [(S)-benzoin-forming] activity and oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor. Located in cytoplasm. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See IRC24 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (422074..422865, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene saccharopine dehydrogenase (NAD+, L-lysine-forming) Neighboring gene sepiapterin reductase family protein Neighboring gene peroxiredoxin HYR1 Neighboring gene bifunctional glutathione transferase/peroxidase

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    sepiapterin reductase family protein IRC24
    NP_012302.3
    • Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; induced by the DNA-damaging agent MMS; null mutant has elevated levels of spontaneous Rad52p foci; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      422074..422865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179558.3NP_012302.3  TPA: sepiapterin reductase family protein IRC24 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012302.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVW7, P40580, Q54AB5
      UniProtKB/TrEMBL
      A6ZVV6, B3LTH4, C7GLS0, C8ZAT8, G2WFW4, N1P4B2
      Conserved Domains (1) summary
      cd05367
      Location:4255
      SPR-like_SDR_c; sepiapterin reductase (SPR)-like, classical (c) SDRs