DAL1 allantoinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DAL1
Official Full Name: allantoinase
Primary source: SGD:S000001466
Locus tag: YIR027C
See related: AllianceGenome:SGD:S000001466; FungiDB:YIR027C; VEuPathDB:YIR027C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables allantoinase activity. Involved in allantoin assimilation pathway. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome; dihydropyrimidinase deficiency; and purine-pyrimidine metabolic disorder. Orthologous to several human genes including CRMP1 (collapsin response mediator protein 1); DPYS (dihydropyrimidinase); and DPYSL2 (dihydropyrimidinase like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DAL1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (406260..407642, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables allantoinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables allantoinase activity	IEA Inferred from Electronic Annotation more info
enables allantoinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cobalt ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in allantoin assimilation pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in allantoin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: allantoinase

NP_012293.3

EC 3.5.2.5

Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

406260..407642 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179549.3 → NP_012293.3 TPA: allantoinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012293.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVV8, P32375

UniProtKB/TrEMBL

B3LTI2, B5VKW3, C7GLS9, N1P2C0

Conserved Domains (1) summary

cd01315
Location:9 → 456

L-HYD_ALN; L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in ...