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    YVH1 tyrosine protein phosphatase YVH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854844, updated on 2-Nov-2024

    Summary

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    Official Symbol
    YVH1
    Official Full Name
    tyrosine protein phosphatase YVH1
    Primary source
    SGD:S000001465
    Locus tag
    YIR026C
    See related
    AllianceGenome:SGD:S000001465; FungiDB:YIR026C; VEuPathDB:YIR026C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables preribosome binding activity and protein tyrosine phosphatase activity. Involved in several processes, including ascospore wall assembly; positive regulation of autophagosome assembly; and ribosome biogenesis. Located in cytoplasm and nucleus. Orthologous to human DUSP12 (dual specificity phosphatase 12). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See YVH1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (404873..405967, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Ina22p Neighboring gene Mnd2p Neighboring gene allantoinase Neighboring gene allantoin permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. Guan K, et al. Proc Natl Acad Sci U S A, 1992 Dec 15. PMID 1334559, Free PMC Article
    2. Yvh1 protein phosphatase is required for pre-autophagosomal structure formation after TORC1 inactivation. Yeasmin AM, et al. Biosci Biotechnol Biochem, 2015. PMID 26125457
    3. The Pyst2-L phosphatase is involved in cell-crowding. Levy-Nissenbaum O, et al. Immunol Lett, 2006 Apr 15. PMID 16386315
    4. The dual-specificity protein phosphatase Yvh1p regulates sporulation, growth, and glycogen accumulation independently of catalytic activity in Saccharomyces cerevisiae via the cyclic AMP-dependent protein kinase cascade. Beeser AE, et al. J Bacteriol, 2000 Jun. PMID 10852885, Free PMC Article
    5. Dual-specificity protein phosphatase Yvh1p, which is required for vegetative growth and sporulation, interacts with yeast pescadillo homolog in Saccharomyces cerevisiae. Sakumoto N, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716519

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yvh1 phosphatase is critical for PAS formation
      Title: Yvh1 protein phosphatase is required for pre-autophagosomal structure formation after TORC1 inactivation.
    2. the interaction between Mrt4 and Yvh1 is also essential for normal glycogen accumulation and mRNA decay as well as the induction of sporulation genes
      Title: Genetic interactions of ribosome maturation factors Yvh1 and Mrt4 influence mRNA decay, glycogen accumulation, and the expression of early meiotic genes in Saccharomyces cerevisiae.
    3. Yvh1 is required for a late maturation step in the 60S biogenesis pathway.
      Title: Yvh1 is required for a late maturation step in the 60S biogenesis pathway.
    4. Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0.
      Title: Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0.
    5. Changes in ribosome biogenesis caused by loss of Yvh1 or specific ribosomal proteins have effects on the plasma membrane, perhaps by producing specific translational changes.
      Title: A mutant plasma membrane protein is stabilized upon loss of Yvh1, a novel ribosome assembly factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables preribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore wall assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine protein phosphatase YVH1
    NP_012292.3
    • Dual specificity protein phosphatase; regulates growth, sporulation, and glycogen accumulation in a cAMP-dependent protein kinase cascade dependent manner; mutants are defective in 60S ribosome assembly; positively regulates pre-autophagosomal structure (PAS) formation upon nitrogen starvation or rapamycin treatment

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      404873..405967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179548.3 → NP_012292.3  TPA: tyrosine protein phosphatase YVH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012292.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVV7, Q02256
      UniProtKB/TrEMBL
      A6ZVU6, C7GLT0, G2WFV4, N1P983
      Conserved Domains (1) summary
      cd14518
      Location:12 → 173
      DSP_fungal_YVH1; dual specificity phosphatase domain of fungal YVH1-like dual specificity protein phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02256.1

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