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    APC9 anaphase promoting complex subunit 9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850792, updated on 19-Jun-2024

    Summary

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    Gene symbol
    APC9
    Gene description
    anaphase promoting complex subunit 9
    Primary source
    FungiDB:YLR102C
    Locus tag
    YLR102C
    See related
    SGD:S000004092; AllianceGenome:SGD:S000004092; VEuPathDB:YLR102C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in chromatin assembly and protein ubiquitination. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See APC9 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (342970..343767, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mim2p Neighboring gene 3-keto-steroid reductase Neighboring gene DNA replication initiation factor CDC45 Neighboring gene Lcl2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-dependent targeting pathway in Saccharomyces cerevisiae plays a critical role in multiple chromatin assembly regulatory steps. Harkness TA, et al. Genetics, 2002 Oct. PMID 12399376, Free PMC Article
    2. The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Carroll CW, et al. Nat Cell Biol, 2002 Nov. PMID 12402045
    3. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. Rudner AD, et al. J Cell Biol, 2000 Jun 26. PMID 10871279, Free PMC Article
    4. Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining. Jessulat M, et al. Mol Cell Biol, 2015 Jul. PMID 25963654, Free PMC Article
    5. Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Ko N, et al. Mol Biol Cell, 2007 Dec. PMID 17942599, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of Apc9p in anaphase-promoting complex/cyclosome-dependent ubiquitination may be limited to the proteolysis of a select number of substrates.
      Title: In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit 9
    NP_013203.1
    • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      342970..343767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181989.1 → NP_013203.1  TPA: anaphase promoting complex subunit 9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYA2, Q12107
      UniProtKB/TrEMBL
      A0A6A5PTZ3, A7A106, B3LT70, B5VN37, C7GQS5, C8ZD73, G2WIU5, N1P6I8
      Conserved Domains (1) summary
      pfam12856
      Location:91 → 170
      ANAPC9; Anaphase-promoting complex subunit 9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12107.1

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