LRRN4CL LRRN4 C-terminal like [Homo sapiens (human)] - Gene

Summary

Official Symbol: LRRN4CLprovided by HGNC
Official Full Name: LRRN4 C-terminal likeprovided by HGNC
Primary source: HGNC:HGNC:33724
See related: Ensembl:ENSG00000177363 AllianceGenome:HGNC:33724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary (RPKM 6.0), endometrium (RPKM 5.9) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (62686406..62689530, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (62675825..62678949, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (62453878..62457002, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation.
Title: CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D11S2560 (e-PCR)
- UniSTS:37928

D11S4063 (e-PCR)
- UniSTS:154160

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

sY3084 (e-PCR)
- UniSTS:515126

D11S4928 (e-PCR)
- UniSTS:31824

RH79802 (e-PCR)
- UniSTS:88688

D15S1477 (e-PCR)
- UniSTS:474482

D11S3114 (e-PCR)
- UniSTS:152207

RH12527 (e-PCR)
- UniSTS:58367

Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LRRN4 C-terminal-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033077.1 RefSeqGene

Range

5370..8494

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_203422.4 → NP_981967.1 LRRN4 C-terminal-like protein precursor

See identical proteins and their annotated locations for NP_981967.1

Status: VALIDATED

Source sequence(s)

AL834319, AP001458

Consensus CDS

CCDS8030.1

UniProtKB/Swiss-Prot

A8K5L9, Q8ND94

Related

ENSP00000325808.4, ENST00000317449.5

Conserved Domains (1) summary

cd00063
Location:83 → 162

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...