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    Ntn5 netrin 5 [ Mus musculus (house mouse) ]

    Gene ID: 243967, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ntn5provided by MGI
    Official Full Name
    netrin 5provided by MGI
    Primary source
    MGI:MGI:2685330
    See related
    Ensembl:ENSMUSG00000070564 AllianceGenome:MGI:2685330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm484
    Summary
    Involved in neurogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including olfactory system; spinal component of peripheral nervous system; tail; trigeminal nerve; and vibrissa. Orthologous to human NTN5 (netrin 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 6.9), cortex adult (RPKM 4.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ntn5 in Genome Data Viewer
    Location:
    7 B3; 7 29.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45333519..45343980)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45684022..45694556)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008 Neighboring gene secretory blood group 1 Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene carbonic anhydrase 11 Neighboring gene D site albumin promoter binding protein Neighboring gene sphingosine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice. Ikegaya S, et al. Front Neurosci, 2020. PMID 33324143, Free PMC Article
    2. Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. Garrett AM, et al. Front Mol Neurosci, 2016. PMID 26858598, Free PMC Article
    3. Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Dali O, et al. Life Sci Alliance, 2024 Feb. PMID 37973188, Free PMC Article
    4. An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina. Visser JJ, et al. Elife, 2015 Dec 2. PMID 26633812, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    netrin-5
    Names
    netrin-1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033356.4 → NP_001028528.2  netrin-5 isoform a precursor

      See identical proteins and their annotated locations for NP_001028528.2

      Status: VALIDATED

      Source sequence(s)
      AC167242
      Consensus CDS
      CCDS39957.1
      UniProtKB/Swiss-Prot
      B9EKG6, Q3UQ22
      Related
      ENSMUSP00000103371.2, ENSMUST00000107742.11
      Conserved Domains (3) summary
      cd00055
      Location:227 → 276
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:313 → 438
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
      cl02806
      Location:78 → 123
      Laminin_N; Laminin N-terminal (Domain VI)

    2. NM_001289692.2 → NP_001276621.1  netrin-5 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC167242
      Consensus CDS
      CCDS80723.1
      UniProtKB/TrEMBL
      S4R1A5
      Related
      ENSMUSP00000138144.2, ENSMUST00000183120.4
      Conserved Domains (2) summary
      cd00055
      Location:227 → 276
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cl02806
      Location:78 → 123
      Laminin_N; Laminin N-terminal (Domain VI)

    3. NM_001289693.2 → NP_001276622.1  netrin-5 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC167242
      Consensus CDS
      CCDS71964.1
      UniProtKB/TrEMBL
      S4R1X6
      Related
      ENSMUSP00000138412.2, ENSMUST00000182750.10
      Conserved Domains (2) summary
      cd00055
      Location:158 → 207
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:244 → 369
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    4. NM_001358870.2 → NP_001345799.1  netrin-5 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC167242
      UniProtKB/TrEMBL
      A0A140H8W8
      Conserved Domains (2) summary
      cd00055
      Location:290 → 339
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:376 → 501
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45333519..45343980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540888.5 → XP_006540951.1  netrin-5 isoform X3

      Conserved Domains (2) summary
      cd00055
      Location:290 → 339
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:366 → 482
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    2. XM_006540890.5 → XP_006540953.1  netrin-5 isoform X5

      Conserved Domains (2) summary
      cd00055
      Location:227 → 276
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:321 → 446
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    3. XM_006540885.5 → XP_006540948.1  netrin-5 isoform X1

      Conserved Domains (2) summary
      cd00055
      Location:290 → 339
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:384 → 509
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    4. XM_036153115.1 → XP_036009008.1  netrin-5 isoform X6

      Conserved Domains (2) summary
      cd00055
      Location:227 → 276
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:295 → 411
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    5. XM_006540889.5 → XP_006540952.1  netrin-5 isoform X4

      Conserved Domains (2) summary
      cd00055
      Location:290 → 339
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:358 → 474
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    6. XM_036153116.1 → XP_036009009.1  netrin-5 isoform X7

      Conserved Domains (2) summary
      cd00055
      Location:158 → 207
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:252 → 377
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    7. XM_006540886.4 → XP_006540949.1  netrin-5 isoform X2

      Conserved Domains (2) summary
      cd00055
      Location:285 → 334
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:379 → 504
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    8. XM_006540893.5 → XP_006540956.1  netrin-5 isoform X9

      Conserved Domains (2) summary
      cd00055
      Location:153 → 202
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:247 → 372
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    9. XM_006540892.4 → XP_006540955.1  netrin-5 isoform X8

      Conserved Domains (2) summary
      cd00055
      Location:158 → 207
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:252 → 377
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

    RNA

    1. XR_391341.5 RNA Sequence

    2. XR_391342.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UQ22.2 GenPept UniProtKB/Swiss-Prot:Q3UQ22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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