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    Vmn2r88 vomeronasal 2, receptor 88 [ Mus musculus (house mouse) ]

    Gene ID: 669149, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Vmn2r88provided by MGI
    Official Full Name
    vomeronasal 2, receptor 88provided by MGI
    Primary source
    MGI:MGI:1316662
    See related
    Ensembl:ENSMUSG00000000606 AllianceGenome:MGI:1316662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V2r3; V2r13
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Vmn2r88 in Genome Data Viewer
    Location:
    14 C1; 14 26.51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51648458..51656984)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51411001..51419527)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36672 Neighboring gene cyclin-dependent kinase 8 pseudogene Neighboring gene predicted gene 7247 Neighboring gene vomeronasal 2, receptor, pseudogene 110 Neighboring gene STARR-positive B cell enhancer mm9_chr14:52034327-52034627 Neighboring gene vomeronasal 2, receptor, pseudogene 111 Neighboring gene vomeronasal 2, receptor 89

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multisensory Logic of Infant-Directed Aggression by Males. Isogai Y, et al. Cell, 2018 Dec 13. PMID 30550786, Free PMC Article
    2. A multigene family encoding a diverse array of putative pheromone receptors in mammals. Matsunami H, et al. Cell, 1997 Aug 22. PMID 9288756
    3. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal 2, receptor 88
    Names
    vomeronasal 2, receptor, 13
    vomeronasal 2, receptor, 3
    vomeronasal organ family 2, receptor, 13
    vomeronasal organ family 2, receptor, 3
    vomeronasal receptor Vmn2r88

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368932.1 → NP_001355861.1  vomeronasal 2, receptor 88 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122858
      Consensus CDS
      CCDS88654.1
      UniProtKB/TrEMBL
      A0A3B2WCB0, F7D4U1
      Related
      ENSMUSP00000125126.3, ENSMUST00000159674.4
      Conserved Domains (3) summary
      cd06365
      Location:40 → 500
      PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      cd15283
      Location:581 → 832
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:510 → 561
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    2. NM_001368934.1 → NP_001355863.1  vomeronasal 2, receptor 88 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122858
      Consensus CDS
      CCDS88655.1
      UniProtKB/TrEMBL
      F6U6R2, O35201
      Related
      ENSMUSP00000124837.3, ENSMUST00000163019.9
      Conserved Domains (1) summary
      cd06365
      Location:40 → 431
      PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    3. NM_001385269.1 → NP_001372198.1  vomeronasal 2, receptor 88 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122858
      UniProtKB/TrEMBL
      A0A3B2W7D8, A0A3B2WCB0
      Related
      ENSMUSP00000156456.2, ENSMUST00000233394.2
      Conserved Domains (3) summary
      cd15283
      Location:582 → 833
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06365
      Location:46 → 500
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:508 → 562
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    4. NM_001385270.1 → NP_001372199.1  vomeronasal 2, receptor 88 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122858
      UniProtKB/TrEMBL
      A0A3B2W498, O35201
      Related
      ENSMUSP00000156821.2, ENSMUST00000233766.2
      Conserved Domains (1) summary
      cl10011
      Location:46 → 432
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51648458..51656984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519400.1 → XP_006519463.1  vomeronasal 2, receptor 88 isoform X1

      UniProtKB/TrEMBL
      A0A3B2WCB0
      Conserved Domains (3) summary
      cd15283
      Location:582 → 833
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:517 → 562
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06365
      Location:46 → 500
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    2. XM_036158822.1 → XP_036014715.1  vomeronasal 2, receptor 88 isoform X4

      UniProtKB/TrEMBL
      A0A3B2WCB0
      Conserved Domains (2) summary
      cd15283
      Location:541 → 792
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06365
      Location:46 → 500
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    3. XM_030247959.1 → XP_030103819.1  vomeronasal 2, receptor 88 isoform X2

      UniProtKB/TrEMBL
      A0A3B2WCB0
      Conserved Domains (3) summary
      cd15283
      Location:583 → 834
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:510 → 563
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06365
      Location:46 → 500
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    4. XM_036158823.1 → XP_036014716.1  vomeronasal 2, receptor 88 isoform X5

      UniProtKB/TrEMBL
      A0A3B2WB46, A0A3B2WDD6
      Related
      ENSMUSP00000156671.2, ENSMUST00000232951.2
      Conserved Domains (2) summary
      cd15283
      Location:506 → 757
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cl10011
      Location:46 → 481
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    5. XM_036158821.1 → XP_036014714.1  vomeronasal 2, receptor 88 isoform X3

      UniProtKB/TrEMBL
      A0A3B2WCB0
      Conserved Domains (3) summary
      cd15283
      Location:579 → 830
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06365
      Location:46 → 498
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:506 → 559
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011686.1: Suppressed sequence

      Description
      NM_011686.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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