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    Rbm25 RNA binding motif protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 67039, updated on 2-Nov-2024

    Summary

    Official Symbol
    Rbm25provided by MGI
    Official Full Name
    RNA binding motif protein 25provided by MGI
    Primary source
    MGI:MGI:1914289
    See related
    Ensembl:ENSMUSG00000010608 AllianceGenome:MGI:1914289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNPC7; 2600011C06Rik; 2610015J01Rik; A130095G20Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Predicted to be located in nuclear speck. Is expressed in central nervous system and sensory organ. Orthologous to human RBM25 (RNA binding motif protein 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 31.0), CNS E14 (RPKM 19.1) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rbm25 in Genome Data Viewer
    Location:
    12 D1; 12 38.81 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83678990..83729901)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83632208..83683127)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9860 Neighboring gene STARR-seq mESC enhancer starr_32707 Neighboring gene STARR-seq mESC enhancer starr_32708 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene zinc finger, FYVE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32712 Neighboring gene STARR-positive B cell enhancer ABC_E1444 Neighboring gene STARR-seq mESC enhancer starr_32714 Neighboring gene STARR-seq mESC enhancer starr_32715 Neighboring gene H2A histone family, member Z pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7159 Neighboring gene presenilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E3061 Neighboring gene farnesyl diphosphate synthetase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364415.1NP_001351344.1  RNA-binding protein 25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC055772
      Conserved Domains (2) summary
      smart00311
      Location:777850
      PWI; domain in splicing factors
      cd12446
      Location:106188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    2. NM_001364416.1NP_001351345.1  RNA-binding protein 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC055772
      Consensus CDS
      CCDS49107.1
      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758831
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    3. NM_027349.4NP_081625.3  RNA-binding protein 25 isoform 2

      See identical proteins and their annotated locations for NP_081625.3

      Status: VALIDATED

      Source sequence(s)
      AC055772, AK011403, AK142132, BY169048, CJ063347
      Consensus CDS
      CCDS49107.1
      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Related
      ENSMUSP00000048470.9, ENSMUST00000048155.16
      Conserved Domains (2) summary
      smart00311
      Location:758831
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      83678990..83729901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157593.1XP_036013486.1  RNA-binding protein 25 isoform X4

      Conserved Domains (2) summary
      smart00311
      Location:740813
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    2. XM_006516166.4XP_006516229.1  RNA-binding protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006516229.1

      Conserved Domains (2) summary
      smart00311
      Location:777850
      PWI; domain in splicing factors
      cd12446
      Location:106188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    3. XM_036157590.1XP_036013483.1  RNA-binding protein 25 isoform X2

      Conserved Domains (2) summary
      smart00311
      Location:759832
      PWI; domain in splicing factors
      cd12446
      Location:106188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    4. XM_006516168.5XP_006516231.1  RNA-binding protein 25 isoform X3

      See identical proteins and their annotated locations for XP_006516231.1

      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758831
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    5. XM_006516164.5XP_006516227.1  RNA-binding protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006516227.1

      Conserved Domains (2) summary
      smart00311
      Location:777850
      PWI; domain in splicing factors
      cd12446
      Location:106188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    6. XM_036157594.1XP_036013487.1  RNA-binding protein 25 isoform X4

      Conserved Domains (2) summary
      smart00311
      Location:740813
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    7. XM_036157595.1XP_036013488.1  RNA-binding protein 25 isoform X4

      Conserved Domains (2) summary
      smart00311
      Location:740813
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    8. XM_030246879.2XP_030102739.1  RNA-binding protein 25 isoform X5

      Conserved Domains (1) summary
      smart00311
      Location:554627
      PWI; domain in splicing factors
    9. XM_036157591.1XP_036013484.1  RNA-binding protein 25 isoform X3

      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758831
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    10. XM_036157596.1XP_036013489.1  RNA-binding protein 25 isoform X5

      Conserved Domains (1) summary
      smart00311
      Location:554627
      PWI; domain in splicing factors
    11. XM_006516165.5XP_006516228.1  RNA-binding protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006516228.1

      Conserved Domains (2) summary
      smart00311
      Location:777850
      PWI; domain in splicing factors
      cd12446
      Location:106188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    12. XM_036157589.1XP_036013482.1  RNA-binding protein 25 isoform X2

      Conserved Domains (2) summary
      smart00311
      Location:759832
      PWI; domain in splicing factors
      cd12446
      Location:106188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    13. XM_036157588.1XP_036013481.1  RNA-binding protein 25 isoform X1

      Conserved Domains (2) summary
      smart00311
      Location:777850
      PWI; domain in splicing factors
      cd12446
      Location:106188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    14. XM_036157592.1XP_036013485.1  RNA-binding protein 25 isoform X3

      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758831
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    15. XM_030246881.2XP_030102741.1  RNA-binding protein 25 isoform X5

      Conserved Domains (1) summary
      smart00311
      Location:554627
      PWI; domain in splicing factors
    16. XM_006516169.5XP_006516232.1  RNA-binding protein 25 isoform X5

      See identical proteins and their annotated locations for XP_006516232.1

      UniProtKB/Swiss-Prot
      B2RY56
      Conserved Domains (1) summary
      smart00311
      Location:554627
      PWI; domain in splicing factors
    17. XM_036157587.1XP_036013480.1  RNA-binding protein 25 isoform X1

      Conserved Domains (2) summary
      smart00311
      Location:777850
      PWI; domain in splicing factors
      cd12446
      Location:106188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    18. XM_030246878.2XP_030102738.1  RNA-binding protein 25 isoform X3

      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758831
      PWI; domain in splicing factors
      cd12446
      Location:87169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins