U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HRH1 histamine receptor H1 [ Homo sapiens (human) ]

    Gene ID: 3269, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HRH1provided by HGNC
    Official Full Name
    histamine receptor H1provided by HGNC
    Primary source
    HGNC:HGNC:5182
    See related
    Ensembl:ENSG00000196639 MIM:600167; AllianceGenome:HGNC:5182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H1R; H1-R; HH1R; hisH1
    Summary
    Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in brain (RPKM 4.0), urinary bladder (RPKM 3.8) and 21 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HRH1 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (11137238..11263557)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (11131678..11258484)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11178924..11305243)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SLC6A1 antisense RNA 1 Neighboring gene solute carrier family 6 member 1 Neighboring gene Sharpr-MPRA regulatory region 1670 Neighboring gene uncharacterized LOC101927467 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:11178289-11179488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19426 Neighboring gene uncharacterized LOC105376951 Neighboring gene uncharacterized LOC124909345 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11208446-11208946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11208947-11209447 Neighboring gene uncharacterized LOC102723663 Neighboring gene Sharpr-MPRA regulatory region 13806 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:11299925-11300126 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:11313687-11314278 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:11314279-11314868 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:11328313-11328445 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:11330264-11331463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19429 Neighboring gene ribosomal protein L13a pseudogene 27 Neighboring gene autophagy related 7 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:11405755-11406954 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:11521898-11522503 Neighboring gene CSTB pseudogene 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. Hishinuma S, et al. J Pharmacol Sci, 2008 May. PMID 18446005
    2. A G(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL). Bruysters M, et al. J Biol Chem, 2005 Oct 14. PMID 16027157
    3. Linking agonist binding to histamine H1 receptor activation. Jongejan A, et al. Nat Chem Biol, 2005 Jul. PMID 16408006
    4. Alternative promoter use and splice variation in the human histamine H1 receptor gene. Swan C, et al. Am J Respir Cell Mol Biol, 2006 Jul. PMID 16484687
    5. Dualistic H(1)-mediated effect of histamine on the human isolated intestine. 5. Histamine in cardiovascular and gastrointestinal systems. Poli E, et al. Inflamm Res, 2006 Apr. PMID 16547808

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2.
      Title: The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2.
    2. Histamine H1 Receptor-Mediated JNK Phosphorylation Is Regulated by Gq Protein-Dependent but Arrestin-Independent Pathways.
      Title: Histamine H(1) Receptor-Mediated JNK Phosphorylation Is Regulated by G(q) Protein-Dependent but Arrestin-Independent Pathways.
    3. Histamine H1- and H4-receptor expression in human colon-derived cell lines.
      Title: Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.
    4. Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H1 Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine.
      Title: Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H(1) Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine.
    5. Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins.
      Title: Differential regulation of histamine H(1) receptor-mediated ERK phosphorylation by G(q) proteins and arrestins.
    6. Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.
      Title: Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.
    7. Molecular Signaling and Transcriptional Regulation of Histamine H1 Receptor Gene.
      Title: Molecular Signaling and Transcriptional Regulation of Histamine H(1) Receptor Gene.
    8. Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase.
      Title: Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase.
    9. P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors.
      Title: P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H(1) Histamine Receptors.
    10. Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30x30)K Variant in the Histamine H1 Receptor.
      Title: Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30×30)K Variant in the Histamine H(1) Receptor.
    Submit: New GeneRIF Correction See all GeneRIFs (85)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histamine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histamine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to histamine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to histamine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    histamine H1 receptor
    Names
    histamine receptor, subclass H1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000861.3 → NP_000852.1  histamine H1 receptor

      See identical proteins and their annotated locations for NP_000852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as H/I/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC083855, BC060802, BM905371, D28481, DB073635
      Consensus CDS
      CCDS2604.1
      UniProtKB/Swiss-Prot
      A8K047, P35367, Q6P9E5
      UniProtKB/TrEMBL
      A8K7Z2
      Related
      ENSP00000380247.1, ENST00000397056.1
      Conserved Domains (1) summary
      cd15050
      Location:28 → 479
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001098211.2 → NP_001091681.1  histamine H1 receptor

      See identical proteins and their annotated locations for NP_001091681.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as F/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC083855, BM905371, D28481, DA372691, DB073635
      Consensus CDS
      CCDS2604.1
      UniProtKB/Swiss-Prot
      A8K047, P35367, Q6P9E5
      UniProtKB/TrEMBL
      A8K7Z2
      Conserved Domains (1) summary
      cd15050
      Location:28 → 479
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001098212.2 → NP_001091682.1  histamine H1 receptor

      See identical proteins and their annotated locations for NP_001091682.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as B/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC083855, BM905371, BP366267, D28481
      Consensus CDS
      CCDS2604.1
      UniProtKB/Swiss-Prot
      A8K047, P35367, Q6P9E5
      UniProtKB/TrEMBL
      A8K7Z2
      Related
      ENSP00000397028.2, ENST00000431010.3
      Conserved Domains (1) summary
      cd15050
      Location:28 → 479
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001098213.2 → NP_001091683.1  histamine H1 receptor

      See identical proteins and their annotated locations for NP_001091683.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as A/K, represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC083855, BM905371, D28481, DB073635, DC300229
      Consensus CDS
      CCDS2604.1
      UniProtKB/Swiss-Prot
      A8K047, P35367, Q6P9E5
      UniProtKB/TrEMBL
      A8K7Z2
      Related
      ENSP00000406705.2, ENST00000438284.2
      Conserved Domains (1) summary
      cd15050
      Location:28 → 479
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      11137238..11263557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      11131678..11258484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35367.1 GenPept UniProtKB/Swiss-Prot:P35367

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous