Rmnd5b required for meiotic nuclear division 5 homolog B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rmnd5bprovided by MGI
Official Full Name: required for meiotic nuclear division 5 homolog Bprovided by MGI
Primary source: MGI:MGI:1913339
See related: Ensembl:ENSMUSG00000001054 AllianceGenome:MGI:1913339
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gid2; 0610039K22Rik
Summary: Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5B (required for meiotic nuclear division 5 homolog B). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 67.7), adrenal adult (RPKM 44.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.15 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (51514500..51526723, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (51623673..51635896, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

General gene information

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Markers

D11Ertd175e (e-PCR), detects polymorphism
- UniSTS:167045

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GID complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein transferase RMND5B

Names: protein RMD5 homolog B

NP_079622.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025346.1 → NP_079622.1 E3 ubiquitin-protein transferase RMND5B

See identical proteins and their annotated locations for NP_079622.1

Status: PROVISIONAL

Source sequence(s)

AK075599

Consensus CDS

CCDS24656.1

UniProtKB/Swiss-Prot

Q91YQ7

Related

ENSMUSP00000001081.4, ENSMUST00000001081.10

Conserved Domains (5) summary

smart00667
Location:116 → 148

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:156 → 212

CTLH; C-terminal to LisH motif

smart00757
Location:210 → 304

CRA; CT11-RanBPM

pfam10607
Location:155 → 299

CLTH; CTLH/CRA C-terminal to LisH motif domain

pfam13445
Location:338 → 377

zf-RING_UBOX; RING-type zinc-finger