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    suhB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947285, updated on 24-Aug-2024

    Summary

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    Official Symbol
    suhB
    Primary source
    ECOCYC:EG10983
    Locus tag
    b2533
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2530; ssyA
    Summary
    The N-terminal sequence was determined using protein made with a synthetic RBS, and thus is not a confirmation of the in vivo start site; the N-terminal Met was not clipped off the recombinant protein. [More information is available at EcoGene: EG10983]. The suhB gene has been shown to encode a protein with inositol monophosphatase and glycerol-2-phosphatase activity . [More information is available at EcoCyc: EG10983].
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    Genomic context

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    Sequence:
    NC_000913.3 (2663442..2664245)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator IscR Neighboring gene tRNA Cm32/Um32 methyltransferase Neighboring gene putative peptidase Neighboring gene stationary phase-inducible protein CsiE Neighboring gene putative 3-phenylpropionate transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis. Huang YH, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31020314, Free PMC Article
    2. SuhB Associates with Nus Factors To Facilitate 30S Ribosome Biogenesis in Escherichia coli. Singh N, et al. mBio, 2016 Mar 15. PMID 26980831, Free PMC Article
    3. The structure of the R184A mutant of the inositol monophosphatase encoded by suhB and implications for its functional interactions in Escherichia coli. Wang Y, et al. J Biol Chem, 2007 Sep 14. PMID 17652087
    4. Autogenous control of the suhB gene expression of Escherichia coli. Inada T, et al. Biochimie, 1996. PMID 8831954
    5. Inositol monophosphatase activity from the Escherichia coli suhB gene product. Matsuhisa A, et al. J Bacteriol, 1995 Jan. PMID 8002619, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis.
      Title: Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis.
    2. SuhB can be integrated into a Nus factor-, and optionally ribosomal protein S4-, containing antitermination complex halted at a ribosomal antitermination signal. Furthermore, SuhB specifically binds to the acidic repeat 2 domain of the multi-domain protein NusA, an interaction that may be involved in antitermination or posttranscriptional processes.
      Title: SuhB is an integral part of the ribosomal antitermination complex and interacts with NusA.
    3. Results reveal functions of SuhB during ribosomal RNA synthesis and delineate some of the underlying molecular interactions.
      Title: Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis.
    4. The authors demonstrate that the main function of this SuhB-containing complex is not to prevent premature transcription termination within the rRNA operon, as had been long claimed, but to enable rRNA maturation and a functional ribosome fully competent for translation.
      Title: SuhB Associates with Nus Factors To Facilitate 30S Ribosome Biogenesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-2-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol monophosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lithium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA primary transcript binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription antitermination factor activity, RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription antitermination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transcription antitermination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nus factor SuhB
    NP_417028.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2663442..2664245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417028.1 Nus factor SuhB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417028.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5N8HJQ7, A0A7A6ZVB9
      Conserved Domains (1) summary
      PRK10757
      Location:1 → 267
      PRK10757; inositol-1-monophosphatase
    Nucleotide Protein
    Heading Accession and Version

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