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    coaA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948479, updated on 24-Aug-2024

    Summary

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    Official Symbol
    coaA
    Primary source
    ECOCYC:EG10922
    Locus tag
    b3974
    See related
    ASAP:ABE-0013003
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3966; panK; rts; ts-9
    Summary
    Pantothenate kinase catalyzes the first step in the biosynthesis of coenzyme A, an essential cofactor that is involved in many reactions. [More information is available at EcoCyc: EG10922].
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    Genomic context

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    Sequence:
    NC_000913.3 (4174076..4175026, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene UDP-N-acetylenolpyruvoylglucosamine reductase Neighboring gene DNA-binding transcriptional repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA Neighboring gene tRNA-Thr Neighboring gene tRNA-Tyr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic studies of the role of fatty acid and coenzyme A in photocatalytic inactivation of Escherichia coli. Gao M, et al. Water Res, 2012 Sep 1. PMID 22691444
    2. One-pot chemo-enzymatic synthesis of reporter-modified proteins. Worthington AS, et al. Org Biomol Chem, 2006 Jan 7. PMID 16357994
    3. Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors. Virga KG, et al. Bioorg Med Chem, 2006 Feb 15. PMID 16213731
    4. Enhanced isoamyl acetate production upon manipulation of the acetyl-CoA node in Escherichia coli. Vadali RV, et al. Biotechnol Prog, 2004 May-Jun. PMID 15176870
    5. The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites. Ivey RA, et al. J Biol Chem, 2004 Aug 20. PMID 15136582

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that while the lower coenzyme A level in coaA(-) mutant correlated well with its lower susceptibility towards photocatalytic inactivation.
      Title: Genetic studies of the role of fatty acid and coenzyme A in photocatalytic inactivation of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantetheine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pantothenate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantothenate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pantothenate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within coenzyme A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pantothenate kinase
    NP_418405.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4174076..4175026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418405.1 pantothenate kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418405.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A830SNX8
      Conserved Domains (1) summary
      TIGR00554
      Location:27 → 316
      panK_bact; pantothenate kinase, bacterial type
    Nucleotide Protein
    Heading Accession and Version

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