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    zinT metal-binding protein ZinT [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946480, updated on 19-Sep-2024

    Summary

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    Official Symbol
    zinT
    Official Full Name
    metal-binding protein ZinT
    Primary source
    ECOCYC:G7061
    Locus tag
    b1973
    See related
    ASAP:ABE-0006546
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1969; yodA
    Summary
    Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG14049]. YodA binds divalent metal ions including cadmium, zinc, and nickel and is proposed to be a generalized stress factor . [More information is available at EcoCyc: G7061].
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    Genomic context

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    Sequence:
    NC_000913.3 (2041375..2042025)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein-L-methionine sulfoxide reductase catalytic subunit MsrP Neighboring gene membrane-bound flavocytochrome MsrQ Neighboring gene putative cytochrome b561 YodB Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of a novel cadmium-induced yodA protein in Escherichia coli. Stojnev T, et al. Curr Microbiol, 2007 Aug. PMID 17632755
    2. Enrichment of Escherichia coli proteins by column chromatography on reactive dye columns. Birch RM, et al. Proteomics, 2003 May. PMID 12748954
    3. Regulation of yodA encoding a novel cadmium-induced protein in Escherichia coli. Puškarova A, et al. Microbiology (Reading), 2002 Dec. PMID 12480884
    4. Crystallization and preliminary analysis of Escherichia coli YodA. David G, et al. Acta Crystallogr D Biol Crystallogr, 2002 Jul. PMID 12077457
    5. Severe zinc depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins. Graham AI, et al. J Biol Chem, 2009 Jul 3. PMID 19377097, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. purified ZinT protein possessed a single, high affinity metal-binding site that can accommodate Zn(2+) or Cd(2+)
      Title: Severe zinc depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins.
    2. ZinT plays a role in zinc homeostasis and is required for growth under zinc limited conditions, suggesting that ZinT is either a periplasmic zinc chaperone or is involved in zinc import.
      Title: Zinc dependence of zinT (yodA) mutants and binding of zinc, cadmium and mercury by ZinT.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: The cadmium-stress stimulon of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to zinc ion starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular zinc ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    metal-binding protein ZinT

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2041375..2042025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416482.1 metal-binding protein ZinT [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416482.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7L512
      Conserved Domains (1) summary
      PRK10306
      Location:1 → 216
      PRK10306; zinc/cadmium-binding protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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